PMID- 10958936
OWN - NLM
STAT- MEDLINE
DCOM- 20000908
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 121
IP  - 1
DP  - 2000 Aug
TI  - Nonrandom rearrangements of 6p in malignant hematological disorders.
PG  - 22-5
AB  - It is very uncommon to observe nontranslocation abnormalities (NTAs) involving 
      the short arm of chromosome 6 (6p) in malignant hematological disorders (MHDs). 
      By using conventional cytogenetics and fluorescence in situ hybridization (FISH) 
      with chromosome-microdissection probes specific for 6p21 and 6p25, we observed 
      five patients with myeloid malignancies and two patients with lymphoid 
      malignancies to have 6p NTAs. On the basis of our data and those in the 
      literature, it is possible to divide 6p NTAs into the following three groups in 
      MHD: The first group presents with 6p NTAs as a sole or primary change in myeloid 
      malignancies. There are only two cases reported in this group, including one case 
      with del(6)(p23) and the present case with ins(6)(q23p23p25) identified by FISH 
      only. The second group presents with 6p deletions as a sole or primary change in 
      lymphoid malignancies. Three cases have been reported in this group, including 
      one case with del(6)(p21p23), one with del(6)(p21), and the present case 2 with 
      del(6)(p21). The third group has 6p deletions in addition to other known primary 
      changes, present in both myeloid and lymphoid disorders, with 36 cases reported, 
      including five cases from our series. Deletions involving 6p21, 6p22, or 6p23 
      have been observed in both myeloid and lymphoid disorders. The present data 
      provide cogent information for further molecular characterization of 6p anomalies 
      in MHD.
FAU - Chen, Z
AU  - Chen Z
AD  - Cytogenetics Laboratory, Division of Medical Genetics, Department of Pediatrics, 
      University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
FAU - Issa, B
AU  - Issa B
FAU - Brothman, L J
AU  - Brothman LJ
FAU - Hendricksen, M
AU  - Hendricksen M
FAU - Button, D
AU  - Button D
FAU - Brothman, A R
AU  - Brothman AR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 6/*genetics
MH  - Female
MH  - Gene Rearrangement
MH  - Hematologic Neoplasms/*genetics
MH  - Hodgkin Disease/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/genetics
MH  - Leukemia, Myelomonocytic, Acute/genetics
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/genetics
EDAT- 2000/08/26 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/08/26 11:00
PHST- 2000/08/26 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/08/26 11:00 [entrez]
AID - S0165-4608(00)00222-3 [pii]
AID - 10.1016/s0165-4608(00)00222-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Aug;121(1):22-5. doi: 10.1016/s0165-4608(00)00222-3.