PMID- 10958938
OWN - NLM
STAT- MEDLINE
DCOM- 20000908
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 121
IP  - 1
DP  - 2000 Aug
TI  - Structural and numerical aberrations of chromosome 22 in a case of follicular 
      variant of papillary thyroid carcinoma revealed by conventional and molecular 
      cytogenetics.
PG  - 33-7
AB  - This study reports a case of papillary carcinoma with vesicular components 
      showing multiclonal aberrations of chromosome 22 as revealed by RHG-banding 
      cytogenetics and by fluorescence in situ hybridization (FISH; whole chromosome 22 
      and BCR-ABL-specific locus probes, multi-FISH). Four clones with chromosome 22 
      changes as the sole abnormality were seen. The main abnormal clone lacked the 
      whole chromosome 22. A del(22)(q11) was observed in a second group of cells. The 
      third clone had an idic(22). Finally, FISH revealed a fourth abnormal cell 
      population with a der(17)t(?17;22). Some of these chromosome 22 alterations have 
      been described in other solid tumors such as meningiomas and neurinomas, 
      suggesting a common genetic pathway of tumor progression occurring in a multistep 
      process. Chromosome 22 changes do not seem to be involved in pure papillary 
      thyroid tumors and therefore could be related to the maintenance of a 
      follicular-type histological pattern.
FAU - Perissel, B
AU  - Perissel B
AD  - Laboratoire d'Histologie-Embryologie-Cytogenetique, Centre Jean-Perrin, 
      Clermont-Ferrand, France.
FAU - Coupier, I
AU  - Coupier I
FAU - De Latour, M
AU  - De Latour M
FAU - Cardot, N
AU  - Cardot N
FAU - Penault-Llorca, F
AU  - Penault-Llorca F
FAU - Jaffray, J
AU  - Jaffray J
FAU - Giollant, M
AU  - Giollant M
FAU - Fonck, Y
AU  - Fonck Y
FAU - Malet, P
AU  - Malet P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Carcinoma, Papillary, Follicular/*genetics/pathology
MH  - Chromosome Aberrations/*genetics
MH  - Chromosome Painting
MH  - Chromosomes, Human, Pair 22/*genetics
MH  - Epithelial Cells/pathology/ultrastructure
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Metaphase
MH  - Thyroid Neoplasms/*genetics/pathology
MH  - Tumor Cells, Cultured
EDAT- 2000/08/26 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/08/26 11:00
PHST- 2000/08/26 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/08/26 11:00 [entrez]
AID - S0165460800002284 [pii]
AID - 10.1016/s0165-4608(00)00228-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Aug;121(1):33-7. doi: 10.1016/s0165-4608(00)00228-4.