PMID- 10958948
OWN - NLM
STAT- MEDLINE
DCOM- 20000908
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 121
IP  - 1
DP  - 2000 Aug
TI  - Molecular characterization of der(15)t(11;15) as a secondary cytogenetic 
      abnormality in acute promyelocytic leukemia with cryptic PML-RAR alpha fusion on 
      17q.
PG  - 90-3
AB  - A case of acute promyelocytic leukemia (APL) with cryptic PML-RAR alpha fusion on 
      17q and add(15p) as a secondary abnormality was characterized using molecular 
      cytogenetic techniques. Spectral karyotyping (SKY) showed that chromosome 11 
      material was added to 15p, forming a der(15)t(11;15), which was refined to 
      der(15)t(11;15)(q13.2;p13) with information obtained by comparative genomic 
      hybridization (CGH). Interstitial insertion of chromosome 15 material into 
      chromosome 17q was found by fluorescence in situ hybridization (FISH) with whole 
      chromosome painting (WCP) probes. This study illustrates the necessity of a 
      combination of molecular cytogenetics to decipher complex karyotypic 
      abnormalities and cryptic translocations in leukemia.
FAU - Wan, T S
AU  - Wan TS
AD  - Hematology Section, Department of Pathology, The University of Hong Kong, Queen 
      Mary Hospital, Hong Kong, People's Republic of China.
FAU - Ma, S K
AU  - Ma SK
FAU - Yip, S F
AU  - Yip SF
FAU - Yeung, Y M
AU  - Yeung YM
FAU - Chan, L C
AU  - Chan LC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein)
SB  - IM
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 15/genetics
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Promyelocytic, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*genetics
MH  - Nucleic Acid Hybridization
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Translocation, Genetic/*genetics
EDAT- 2000/08/26 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/08/26 11:00
PHST- 2000/08/26 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/08/26 11:00 [entrez]
AID - S0165-4608(00)00234-X [pii]
AID - 10.1016/s0165-4608(00)00234-x [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Aug;121(1):90-3. doi: 10.1016/s0165-4608(00)00234-x.