PMID- 10959251
OWN - NLM
STAT- MEDLINE
DCOM- 20000912
LR  - 20061115
IS  - 1085-9489 (Print)
IS  - 1085-9489 (Linking)
VI  - 3
IP  - 3
DP  - 1998
TI  - Differential in vitro modulation of Schwann cell proliferation by Mycobacterium 
      leprae and macrophages in the murine strains, Swiss white and C57Bl/6.
PG  - 207-16
AB  - The special susceptibility of Schwann cells (SCs) to parasitization by M. leprae 
      and of macrophages to M. leprae-induced defects implicates them in leprous nerve 
      pathogenesis. SC proliferation is an important prerequisite for peripheral nerve 
      regeneration and is regulated by a number of secretory factors. Several of these 
      factors are secreted by SCs themselves as well as by the macrophages which are 
      recruited at the site of lesion to assist in regeneration. SC proliferation, as 
      indicated by 3H-thymidine incorporation, was therefore studied in response to M. 
      leprae infection and in the presence of macrophages in order to determine the 
      role of SC in leprous neuropathy. Cells derived from two strains of mice, Swiss 
      White (SW) and C57Bl/6 were used, as macrophages from these strains have been 
      shown to differ in their response to M. leprae; such differences are similar to 
      those observed in macrophages from lepromatous and tuberculoid leprosy patients, 
      respectively. Infection with M. leprae for a duration of 9 days resulted in 
      reduced proliferation of SCs from SW strain, while SCs from C57Bl/6 remained 
      unaffected. However, in the presence of macrophages, SCs from both strains not 
      only showed enhanced proliferation, but SW SCs also overcame the M. 
      leprae-induced suppression of their proliferation. Altered SC proliferation, 
      therefore, can be implicated as a factor in leprous nerve pathogenesis. The 
      strain variation observed in the response of SCs indicate different nerve damage 
      mechanisms in lepromatous and tuberculoid patients.
FAU - Singh, N
AU  - Singh N
AD  - Foundation for Medical Research, Worli, Bombay, India.
FAU - Birdi, T J
AU  - Birdi TJ
FAU - Antia, N H
AU  - Antia NH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Peripher Nerv Syst
JT  - Journal of the peripheral nervous system : JPNS
JID - 9704532
SB  - IM
MH  - Animals
MH  - Cell Division/physiology
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Leprosy/*pathology
MH  - Macrophages/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Mycobacterium leprae/physiology
MH  - Schwann Cells/*cytology/*microbiology/pathology
EDAT- 2000/08/26 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/08/26 11:00
PHST- 2000/08/26 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/08/26 11:00 [entrez]
PST - ppublish
SO  - J Peripher Nerv Syst. 1998;3(3):207-16.