PMID- 10960358
OWN - NLM
STAT- MEDLINE
DCOM- 20001005
LR  - 20171213
IS  - 0193-1857 (Print)
IS  - 0193-1857 (Linking)
VI  - 279
IP  - 3
DP  - 2000 Sep
TI  - TNF-alpha activates solitary nucleus neurons responsive to gastric distension.
PG  - G582-6
AB  - Tumor necrosis factor-alpha (TNF-alpha) is liberated as part of the immune 
      response to antigenic challenge, carcinogenesis, and radiation therapy. Previous 
      studies have implicated elevated circulating levels of this cytokine in the 
      gastric hypomotility associated with these disease states. Our earlier studies 
      suggest that a site of action of TNF-alpha may be within the medullary dorsal 
      vagal complex. In this study, we describe the role of TNF-alpha as a 
      neuromodulator affecting neurons in the nucleus of the solitary tract that are 
      involved in vago-vagal reflex control of gastric motility. The results presented 
      herein suggest that TNF-alpha may induce a persistent gastric stasis by 
      functioning as a hormone that modulates intrinsic vago-vagal reflex pathways 
      during illness.
FAU - Emch, G S
AU  - Emch GS
AD  - Department of Neuroscience, College of Medicine, Ohio Sate University, Columbus, 
      Ohio 43210, USA.
FAU - Hermann, G E
AU  - Hermann GE
FAU - Rogers, R C
AU  - Rogers RC
LA  - eng
GR  - DK-52142/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol Gastrointest Liver Physiol
JT  - American journal of physiology. Gastrointestinal and liver physiology
JID - 100901227
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Gastric Dilatation/*physiopathology
MH  - Gastric Emptying/physiology
MH  - Male
MH  - Microinjections
MH  - Neurons/drug effects/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Reflex/physiology
MH  - Solitary Nucleus/cytology/drug effects/*physiology
MH  - Stomach/*innervation/physiology
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Vagus Nerve/physiology
EDAT- 2000/08/29 11:00
MHDA- 2000/10/07 11:01
CRDT- 2000/08/29 11:00
PHST- 2000/08/29 11:00 [pubmed]
PHST- 2000/10/07 11:01 [medline]
PHST- 2000/08/29 11:00 [entrez]
AID - 10.1152/ajpgi.2000.279.3.G582 [doi]
PST - ppublish
SO  - Am J Physiol Gastrointest Liver Physiol. 2000 Sep;279(3):G582-6. doi: 
      10.1152/ajpgi.2000.279.3.G582.