PMID- 10963075
OWN - NLM
STAT- MEDLINE
DCOM- 20001222
LR  - 20201214
IS  - 1297-319X (Print)
IS  - 1297-319X (Linking)
VI  - 67
IP  - 4
DP  - 2000
TI  - Fas ligand and Bax gene transcription contributes to Ro60 ribonucleoprotein 
      redistribution in UV-A irradiated human keratinocytes.
PG  - 283-9
AB  - OBJECTIVES: Ro ribonucleoproteins are of particular interest because they are 
      serologic markers of photosensitive variants of lupus such as the subacute 
      cutaneous lupus erythematosus (SCLE), in which the polycyclic skin lesions are 
      triggered by exposure to the sun. We study the role of apoptosis in the 
      expression of Ro antigen. METHODS: We used UV-A irradiated keratinocytes. 
      RESULTS: We demonstrate in cultured human UVA-irradiated keratinocytes that the 
      enhanced expression of Ro60 ribonucleoprotein is caused by antigenic 
      redistribution consecutive to Fas-L and Bax gene activation.
FAU - Bollain-y-Goytia, J J
AU  - Bollain-y-Goytia JJ
AD  - Department of Immunology, CBE, Universidad Autonoma de Zacatecas, Guadelupe, 
      Mexico.
FAU - Avalos-Diaz, E
AU  - Avalos-Diaz E
FAU - Herrera-Esparza, R
AU  - Herrera-Esparza R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Joint Bone Spine
JT  - Joint bone spine
JID - 100938016
RN  - 0 (Autoantigens)
RN  - 0 (BAX protein, human)
RN  - 0 (FASLG protein, human)
RN  - 0 (Fas Ligand Protein)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (RNA, Small Cytoplasmic)
RN  - 0 (RO60 protein, human)
RN  - 0 (Ribonucleoproteins)
RN  - 0 (bcl-2-Associated X Protein)
SB  - IM
MH  - Apoptosis/*genetics
MH  - Autoantigens/*metabolism/radiation effects
MH  - Blotting, Western
MH  - Cells, Cultured
MH  - Fas Ligand Protein
MH  - Fluorescent Antibody Technique, Indirect
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - In Situ Hybridization
MH  - Keratinocytes/metabolism/*radiation effects
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Proto-Oncogene Proteins/*genetics
MH  - *Proto-Oncogene Proteins c-bcl-2
MH  - *RNA, Small Cytoplasmic
MH  - Ribonucleoproteins/*metabolism/radiation effects
MH  - *Transcription, Genetic
MH  - Ultraviolet Rays
MH  - bcl-2-Associated X Protein
EDAT- 2000/08/30 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/30 11:00
PHST- 2000/08/30 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/30 11:00 [entrez]
PST - ppublish
SO  - Joint Bone Spine. 2000;67(4):283-9.