PMID- 10963760
OWN - NLM
STAT- MEDLINE
DCOM- 20001103
LR  - 20191210
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 39
IP  - 11
DP  - 2000 Aug 23
TI  - Effects of strain and serotonergic agents on prepulse inhibition and habituation 
      in mice.
PG  - 2170-9
AB  - Neural sensorimotor gating mechanisms prevent the interruption of ongoing 
      information processing routines by ensuing stimuli to permit mental integration 
      and adaptive behavior. Prepulse inhibition (PPI), an operational measure of 
      sensorimotor gating, is now being investigated using murine models to exploit 
      transgenic and "knockout" technology. The present studies were undertaken to 
      evaluate potential murine strain differences in the effects of serotonergic drugs 
      on PPI and habituation. Two strains used most often as a genetic background for 
      transgenic or knockout manipulations, C57BL/6 and 129Sv, and the outbred ICR 
      strain were used. We assessed the effects of the 5-HT(1A/1B) agonist 
      5-methoxy-3(1,2,3,6)tetrahydropyridin-4-yl-1H-indole (RU24969), the 5-HT(1A) 
      agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT), the 5-HT(2A/2C) 
      agonist (+/-)2,5-dimethoxy-4-methylamphetamine (DOM), and the serotonin releaser 
      (+)3, 4-methylenedioxy-N-methylamphetamine (MDMA) on PPI and habituation of 
      acoustic startle in the three strains. C57BL/6 mice exhibited lower baseline PPI 
      levels than 129Sv and ICR mice, and 129Sv mice habituated less than C57BL/6 and 
      ICR mice. MDMA decreased PPI in C57BL/6 and ICR, but not 129Sv mice, and RU24969 
      disrupted habituation in C57BL/6 and 129Sv, but not ICR mice. Lastly, RU24969 
      decreased and 8-OH-DPAT increased PPI across all strains, although qualitative 
      differences were observed. Thus, both baseline and serotonergic drug-induced 
      effects on murine PPI and habituation are strain-dependent.
FAU - Dulawa, S C
AU  - Dulawa SC
AD  - Department of Neuroscience, University of California at San Diego, 9500 Gilman 
      Drive, La Jolla, CA 92093-0804, USA.
FAU - Geyer, M A
AU  - Geyer MA
LA  - eng
GR  - F31-MH12249-01/MH/NIMH NIH HHS/United States
GR  - R02 DA02925/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Serotonin Agents)
SB  - IM
MH  - Animals
MH  - Female
MH  - Habituation, Psychophysiologic/*drug effects/genetics
MH  - *Inhibition, Psychological
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred ICR
MH  - Reflex, Startle/*drug effects/genetics
MH  - Serotonin Agents/*pharmacology
MH  - Species Specificity
EDAT- 2000/08/30 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/30 11:00
PHST- 2000/08/30 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/30 11:00 [entrez]
AID - S0028390800000307 [pii]
AID - 10.1016/s0028-3908(00)00030-7 [doi]
PST - ppublish
SO  - Neuropharmacology. 2000 Aug 23;39(11):2170-9. doi: 10.1016/s0028-3908(00)00030-7.