PMID- 10964689
OWN - NLM
STAT- MEDLINE
DCOM- 20001003
LR  - 20131121
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 275
IP  - 2
DP  - 2000 Aug 28
TI  - Gene expression of neurotrophins and their receptors in lead nitrate-induced rat 
      liver hyperplasia.
PG  - 472-6
AB  - Neurotrophins including nerve growth factor (NGF), brain-derived neurotrophic 
      factor (BDNF), and neurotrophin-3 (NT-3) are known to play important roles in the 
      survival, proliferation, differentiation, and/or maintenance of function in 
      several tissues including neuronal tissues. The role of neurotrophins in liver 
      tissue, however, has not yet been clarified. In the present study, we assessed 
      the temporal change in gene expression of neurotrophins, NGF, BDNF, and NT-3, and 
      their receptors, low affinity neurotrophin receptor (p75NTR) and Trks A, B, and 
      C, by RT-PCR technique in the liver of rats treated with lead nitrate (LN; 0.1 
      mmol/kg body weight), an inducer of liver hyperplasia. The mRNAs for NGF, BDNF 
      with exon 4, NT-3, p75NTR, and all Trk members were detected in the LN-untreated 
      liver. LN treatment resulted in increases in the levels of NGF, BDNF with exon 4, 
      NT-3, p75NTR, and TrkA mRNAs and further led to expression of BDNF mRNA with exon 
      3. The increase in gene expression of neurotrophins and their receptors was 
      closely correlated with those in liver weight. In this report, we propose for the 
      first time that neurotrophins may play crucial roles in LN-induced liver 
      hyperplasia.
CI  - Copyright 2000 Academic Press.
FAU - Nemoto, K
AU  - Nemoto K
AD  - Department of Molecular Toxicology, School of Pharmaceutical Sciences, University 
      of Shizuoka, 52-1 Yada, Shizuoka, 422-8526, Japan. 
      nemoto@ys7.u-shizuoka-ken.ac.jp
FAU - Miyata, S
AU  - Miyata S
FAU - Nemoto, F
AU  - Nemoto F
FAU - Yasumoto, T
AU  - Yasumoto T
FAU - Murai, U
AU  - Murai U
FAU - Kageyama, H
AU  - Kageyama H
FAU - Degawa, M
AU  - Degawa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA Primers)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nitrates)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 2P299V784P (Lead)
RN  - 6E5P1699FI (lead nitrate)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - DNA Primers
MH  - Gene Expression/*drug effects
MH  - Hyperplasia
MH  - Lead/*pharmacology
MH  - Liver/*drug effects/pathology
MH  - Male
MH  - Nerve Growth Factors/*genetics
MH  - Nitrates/*pharmacology
MH  - Organ Size
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Nerve Growth Factor/genetics
EDAT- 2000/08/31 11:00
MHDA- 2000/10/07 11:01
CRDT- 2000/08/31 11:00
PHST- 2000/08/31 11:00 [pubmed]
PHST- 2000/10/07 11:01 [medline]
PHST- 2000/08/31 11:00 [entrez]
AID - S0006-291X(00)93340-0 [pii]
AID - 10.1006/bbrc.2000.3340 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2000 Aug 28;275(2):472-6. doi: 
      10.1006/bbrc.2000.3340.