PMID- 10966476
OWN - NLM
STAT- MEDLINE
DCOM- 20001212
LR  - 20220224
IS  - 0066-4154 (Print)
IS  - 0066-4154 (Linking)
VI  - 69
DP  - 2000
TI  - GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein 
      signaling (RGS) and RGS-like proteins.
PG  - 795-827
AB  - GTPase-activating proteins (GAPs) regulate heterotrimeric G proteins by 
      increasing the rates at which their subunits hydrolyze bound GTP and thus return 
      to the inactive state. G protein GAPs act allosterically on G subunits, in 
      contrast to GAPs for the Ras-like monomeric GTP-binding proteins. Although they 
      do not contribute directly to the chemistry of GTP hydrolysis, G protein GAPs can 
      accelerate hydrolysis >2000-fold. G protein GAPs include both effector proteins 
      (phospholipase C- inverted question mark, p115RhoGEF) and a growing family of regulators of G protein 
      signaling (RGS proteins) that are found throughout the animal and fungal 
      kingdoms. GAP activity can sharpen the termination of a signal upon removal of 
      stimulus, attenuate a signal either as a feedback inhibitor or in response to a 
      second input, promote regulatory association of other proteins, or redirect 
      signaling within a G protein signaling network. GAPs are regulated by various 
      controls of their cellular concentrations, by complex interactions with G inverted question mark or 
      with G inverted question mark5 through an endogenous G-like domain, and by interaction with multiple 
      other proteins.
FAU - Ross, E M
AU  - Ross EM
AD  - Department of Pharmacology, University of Texas Southwestern Medical Center, 
      Dallas, Texas 75390-9041, USA. ross@utsw.swmed.edu
FAU - Wilkie, T M
AU  - Wilkie TM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Biochem
JT  - Annual review of biochemistry
JID - 2985150R
RN  - 0 (GTPase-Activating Proteins)
RN  - 0 (Potassium Channels)
RN  - 0 (RGS Proteins)
RN  - EC 3.6.5.1 (Heterotrimeric GTP-Binding Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Caenorhabditis elegans/genetics/metabolism
MH  - Conserved Sequence
MH  - GTPase-Activating Proteins/*chemistry/genetics/*metabolism
MH  - Heterotrimeric GTP-Binding Proteins/*chemistry/genetics/*metabolism
MH  - Humans
MH  - Models, Biological
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Potassium Channels/metabolism
MH  - Protein Structure, Tertiary
MH  - RGS Proteins/*chemistry/genetics/*metabolism
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
RF  - 181
EDAT- 2000/08/31 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/08/31 11:00
PHST- 2000/08/31 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/08/31 11:00 [entrez]
AID - 69/1/795 [pii]
AID - 10.1146/annurev.biochem.69.1.795 [doi]
PST - ppublish
SO  - Annu Rev Biochem. 2000;69:795-827. doi: 10.1146/annurev.biochem.69.1.795.