PMID- 10966852 OWN - NLM STAT- MEDLINE DCOM- 20001018 LR - 20051116 IS - 1044-579X (Print) IS - 1044-579X (Linking) VI - 10 IP - 4 DP - 2000 Aug TI - Multiple endocrine neoplasia type 1. PG - 299-312 AB - The recent cloning of the gene responsible for multiple endocrine neoplasia type 1 (MEN 1) has opened new avenues for both clinical and basic science research in the field of endocrine oncology. A large amount of genetic information, particularly those in relation to germline and somatic mutations, has since been published during the last 2 years. This new knowledge has provided important insights into its gene function. The significance of these advances in relation to clinical management and future directions for research is discussed. CI - Copyright 2000 Academic Press. FAU - Ki Wong, F AU - Ki Wong F AD - Department of Molecular Medicine, CMM L8:01, Karolinska Hospital, Stockholm, S-17176, Sweden. FAU - Burgess, J AU - Burgess J FAU - Nordenskjold, M AU - Nordenskjold M FAU - Larsson, C AU - Larsson C FAU - Tean Teh, B AU - Tean Teh B LA - eng PT - Journal Article PT - Review PL - England TA - Semin Cancer Biol JT - Seminars in cancer biology JID - 9010218 RN - 0 (Neoplasm Proteins) SB - IM MH - Animals MH - Chromosome Mapping MH - Cloning, Molecular MH - Genotype MH - Humans MH - Multiple Endocrine Neoplasia Type 1/*genetics MH - Mutation/genetics MH - Neoplasm Proteins/metabolism MH - Phenotype MH - Risk Factors RF - 102 EDAT- 2000/09/01 11:00 MHDA- 2000/10/21 11:01 CRDT- 2000/09/01 11:00 PHST- 2000/09/01 11:00 [pubmed] PHST- 2000/10/21 11:01 [medline] PHST- 2000/09/01 11:00 [entrez] AID - S1044-579X(00)90150-0 [pii] AID - 10.1006/scbi.2000.0150 [doi] PST - ppublish SO - Semin Cancer Biol. 2000 Aug;10(4):299-312. doi: 10.1006/scbi.2000.0150.