PMID- 10968783
OWN - NLM
STAT- MEDLINE
DCOM- 20000914
LR  - 20220310
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 289
IP  - 5484
DP  - 2000 Sep 1
TI  - Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR 
      heterodimers.
PG  - 1524-9
AB  - Several nuclear hormone receptors involved in lipid metabolism form obligate 
      heterodimers with retinoid X receptors (RXRs) and are activated by RXR agonists 
      such as rexinoids. Animals treated with rexinoids exhibited marked changes in 
      cholesterol balance, including inhibition of cholesterol absorption and repressed 
      bile acid synthesis. Studies with receptor-selective agonists revealed that 
      oxysterol receptors (LXRs) and the bile acid receptor (FXR) are the RXR 
      heterodimeric partners that mediate these effects by regulating expression of the 
      reverse cholesterol transporter, ABC1, and the rate-limiting enzyme of bile acid 
      synthesis, CYP7A1, respectively. Thus, these RXR heterodimers serve as key 
      regulators of cholesterol homeostasis by governing reverse cholesterol transport 
      from peripheral tissues, bile acid synthesis in liver, and cholesterol absorption 
      in intestine.
FAU - Repa, J J
AU  - Repa JJ
AD  - Howard Hughes Medical Institute and Department of Pharmacology, University of 
      Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 
      75390-9050, USA.
FAU - Turley, S D
AU  - Turley SD
FAU - Lobaccaro, J A
AU  - Lobaccaro JA
FAU - Medina, J
AU  - Medina J
FAU - Li, L
AU  - Li L
FAU - Lustig, K
AU  - Lustig K
FAU - Shan, B
AU  - Shan B
FAU - Heyman, R A
AU  - Heyman RA
FAU - Dietschy, J M
AU  - Dietschy JM
FAU - Mangelsdorf, D J
AU  - Mangelsdorf DJ
LA  - eng
GR  - R37 HL 09610/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (ATP Binding Cassette Transporter 1)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Bile Acids and Salts)
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Ligands)
RN  - 0 (Liver X Receptors)
RN  - 0 (Orphan Nuclear Receptors)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 0C5V0MRU6P (farnesoid X-activated receptor)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.14.14.23 (Cholesterol 7-alpha-Hydroxylase)
SB  - IM
CIN - Science. 2000 Sep 1;289(5484):1446-7. PMID: 10991725
MH  - ATP Binding Cassette Transporter 1
MH  - ATP-Binding Cassette Transporters/genetics/*metabolism
MH  - Animals
MH  - Bile Acids and Salts/biosynthesis
MH  - Biological Transport/drug effects
MH  - Cholesterol/*metabolism
MH  - Cholesterol 7-alpha-Hydroxylase/metabolism
MH  - Cholesterol, Dietary/administration & dosage
MH  - Cricetinae
MH  - DNA-Binding Proteins/metabolism
MH  - Dimerization
MH  - Gene Expression Regulation/drug effects
MH  - Glycoproteins/genetics/*metabolism
MH  - Homeostasis/drug effects
MH  - Intestinal Absorption/*drug effects
MH  - Intestine, Small/*metabolism
MH  - Ligands
MH  - Liver/*metabolism
MH  - Liver X Receptors
MH  - Macrophages, Peritoneal/metabolism
MH  - Male
MH  - Mesocricetus
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Orphan Nuclear Receptors
MH  - *Receptors, Cytoplasmic and Nuclear
MH  - Receptors, Retinoic Acid/agonists/genetics/*metabolism
MH  - Receptors, Thyroid Hormone/agonists/genetics/metabolism
MH  - Retinoid X Receptors
MH  - Transcription Factors/agonists/*metabolism
EDAT- 2000/09/01 11:00
MHDA- 2000/09/19 11:01
CRDT- 2000/09/01 11:00
PHST- 2000/09/01 11:00 [pubmed]
PHST- 2000/09/19 11:01 [medline]
PHST- 2000/09/01 11:00 [entrez]
AID - 8797 [pii]
AID - 10.1126/science.289.5484.1524 [doi]
PST - ppublish
SO  - Science. 2000 Sep 1;289(5484):1524-9. doi: 10.1126/science.289.5484.1524.