PMID- 10971391
OWN - NLM
STAT- MEDLINE
DCOM- 20001002
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 110
IP  - 2
DP  - 2000 Aug
TI  - Mapping of leukaemia-associated breakpoints in chromosome band 3q21 using a newly 
      established PAC contig.
PG  - 343-50
AB  - Chromosome aberrations affecting band 3q21 are associated with a particularly 
      poor prognosis in patients with acute myeloid leukaemia. To facilitate the 
      molecular characterization of such rearrangements, we established a PAC contig 
      covering the relevant genomic region. Using these PACs as probes in fluorescence 
      in situ hybridization (FISH) experiments, we showed that a number of 3q21 
      breakpoints in patient samples map to a previously defined 'breakpoint cluster 
      region'. Others, however, are located at varying distances centromeric of it. 
      These results have important implications in the search for genes affected by 
      3q21 rearrangements.
FAU - Wieser, R
AU  - Wieser R
AD  - Institut fur Medizinische Biologie der Universitat Wien, Austria. 
      rotraud.wieser@univie.ac.at
FAU - Volz, A
AU  - Volz A
FAU - Schnittger, S
AU  - Schnittger S
FAU - Jager, U
AU  - Jager U
FAU - Gruner, H
AU  - Gruner H
FAU - Meran, J G
AU  - Meran JG
FAU - Wimmer, K
AU  - Wimmer K
FAU - Ziegler, A
AU  - Ziegler A
FAU - Fonatsch, C
AU  - Fonatsch C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Chromosome Breakage/*genetics
MH  - Chromosomes, Human, Pair 3/*genetics
MH  - Contig Mapping/*methods
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 2000/09/06 11:00
MHDA- 2000/10/07 11:01
CRDT- 2000/09/06 11:00
PHST- 2000/09/06 11:00 [pubmed]
PHST- 2000/10/07 11:01 [medline]
PHST- 2000/09/06 11:00 [entrez]
AID - bjh2192 [pii]
AID - 10.1046/j.1365-2141.2000.02192.x [doi]
PST - ppublish
SO  - Br J Haematol. 2000 Aug;110(2):343-50. doi: 10.1046/j.1365-2141.2000.02192.x.