PMID- 10971457
OWN - NLM
STAT- MEDLINE
DCOM- 20001010
LR  - 20190813
IS  - 0300-0664 (Print)
IS  - 0300-0664 (Linking)
VI  - 53
IP  - 3
DP  - 2000 Sep
TI  - Plasma concentrations of tumor necrosis factor-alpha (TNF-alpha) and soluble TNF 
      receptors in patients with bulimia nervosa.
PG  - 383-8
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a cytokine with numerous 
      immunological and metabolic activities. In addition, TNF-alpha can stimulate a 
      variety of physiological, neuroendocrine and behavioural responses of the central 
      nervous system. In experimental animals, TNF-alpha induces changes in 
      physiological and behavioural parameters which have also been observed in eating 
      disorders. The biological activities of TNF-alpha are mediated by two 
      structurally related, but functionally distinct receptors, TNF-RI and TNF-RII. 
      Since injection of TNF-alpha results in increased shedding of TNF-alpha 
      receptors, it is likely that TNF-alpha release is reflected by soluble 
      TNF-receptors (sTNF-Rs) levels. AIMS: We studied plasma concentrations of 
      TNF-alpha and two sTNF-Rs (sTNF-RI and sTNF-RII) in female patients with bulimia 
      nervosa. DESIGN AND PATIENTS: Twenty female patients with bulimia nervosa (BN) 
      and 20 age-matched normal women (N) were studied. MEASUREMENTS: Plasma TNF-alpha 
      concentrations were measured by enzyme immunoassay kit and plasma concentrations 
      of sTNF-RI and sTNF-RII were measured by enzyme-linked immunosorbent assay. 
      RESULTS: Plasma TNF-alpha concentrations in BN were significantly higher than 
      those in N (4.7+/- 0.5 ng/l vs. 1.6+/-0.1 ng/l; P<0.01). Although no significant 
      difference was observed in plasma sTNF-RI concentrations between the two groups, 
      plasma sTNF-RII concentrations in BN were significantly higher than those in N 
      (2080.0+/-107.5 ng/l vs. 1569.5 +/-84.0 ng/l; P<0.01). Plasma TNF-alpha 
      concentrations were significantly related to plasma sTNF-RI concentrations (r = 
      0.511, P<0.05) and to plasma sTNF-RII concentrations (r = 0.532, P<0.05) in 
      bulimic patients. However, plasma TNF-alpha concentrations were not related to 
      body fat mass or to bulimic behaviours in these patients. CONCLUSIONS: Our 
      present findings suggest that the adipose tissue may not be the immediate source 
      of TNF-alpha in bulimic patients but the increase in plasma TNF-alpha in these 
      patients may be derived from the central nervous system sources. The elevated 
      sTNF-RII may reflect different shedding kinetics compared with sTNF-RI in bulimic 
      patients.
FAU - Nakai, Y
AU  - Nakai Y
AD  - College of Medical Technology, Kyoto University, Japan. yn@itan.kyoto-u.ac.jp
FAU - Hamagaki, S
AU  - Hamagaki S
FAU - Takagi, R
AU  - Takagi R
FAU - Taniguchi, A
AU  - Taniguchi A
FAU - Kurimoto, F
AU  - Kurimoto F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Antigens, CD)
RN  - 0 (Leptin)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Antigens, CD/blood
MH  - Body Composition
MH  - Bulimia/*blood
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Leptin/blood
MH  - Linear Models
MH  - Receptors, Tumor Necrosis Factor/*blood
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Receptors, Tumor Necrosis Factor, Type II
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 2000/09/06 11:00
MHDA- 2000/10/14 11:01
CRDT- 2000/09/06 11:00
PHST- 2000/09/06 11:00 [pubmed]
PHST- 2000/10/14 11:01 [medline]
PHST- 2000/09/06 11:00 [entrez]
AID - cen1091 [pii]
AID - 10.1046/j.1365-2265.2000.01091.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2000 Sep;53(3):383-8. doi: 
      10.1046/j.1365-2265.2000.01091.x.