PMID- 10971508
OWN - NLM
STAT- MEDLINE
DCOM- 20000918
LR  - 20240314
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 121
IP  - 3
DP  - 2000 Sep
TI  - Significance of chemokines and activated platelets in patients with diabetes.
PG  - 437-43
AB  - Levels of platelet-derived microparticles (PMPs), platelet activation markers 
      (P-selectin expressed on, or annexin V binding to, platelets (plt:P-selectin or 
      plt:annexin V, respectively)), chemokines (IL-8, monocyte chemotactic peptide-1 
      (MCP-1), and regulated on activation normally T-cell expressed and secreted 
      (RANTES)), and soluble P- and E-selectins were compared in peripheral blood from 
      diabetic and control patients in order to develop a better understanding of their 
      potential contribution to diabetic vascular complications. Significant increases 
      were found for PMPs, plt:P-selectin, MCP-1, RANTES and soluble P- and E-selectins 
      in diabetic individuals, whereas IL-8 levels were similar. Furthermore, after 
      ticlopidine treatment, most of these factors receded to baseline levels observed 
      in non-diabetic patients. Our findings indicate that ticlopidine might be able to 
      prevent or reduce vascular complications in diabetic patients.
FAU - Nomura, S
AU  - Nomura S
AD  - First Department of Internal Medicine, Kansai Medical University, Osaka, Japan. 
      fwkg4681@mb.infoweb.ne.jp
FAU - Shouzu, A
AU  - Shouzu A
FAU - Omoto, S
AU  - Omoto S
FAU - Nishikawa, M
AU  - Nishikawa M
FAU - Fukuhara, S
AU  - Fukuhara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Annexin A5)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokines)
RN  - 0 (E-Selectin)
RN  - 0 (Interleukin-8)
RN  - 0 (P-Selectin)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - OM90ZUW7M1 (Ticlopidine)
SB  - IM
MH  - Adult
MH  - Annexin A5/blood
MH  - Blood Platelets/immunology/metabolism
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood
MH  - Chemokine CCL5/blood
MH  - Chemokines/*blood
MH  - Diabetes Mellitus, Type 2/*blood/drug therapy/*immunology
MH  - Diabetic Angiopathies/prevention & control
MH  - E-Selectin/blood
MH  - Female
MH  - Humans
MH  - Interleukin-8/blood
MH  - Male
MH  - Middle Aged
MH  - P-Selectin/blood
MH  - *Platelet Activation
MH  - Platelet Aggregation Inhibitors/pharmacology
MH  - Ticlopidine/pharmacology
PMC - PMC1905738
EDAT- 2000/09/06 11:00
MHDA- 2000/09/23 11:01
PMCR- 2001/09/01
CRDT- 2000/09/06 11:00
PHST- 2000/09/06 11:00 [pubmed]
PHST- 2000/09/23 11:01 [medline]
PHST- 2000/09/06 11:00 [entrez]
PHST- 2001/09/01 00:00 [pmc-release]
AID - cei1324 [pii]
AID - 10.1046/j.1365-2249.2000.01324.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2000 Sep;121(3):437-43. doi: 10.1046/j.1365-2249.2000.01324.x.