PMID- 10971602
OWN - NLM
STAT- MEDLINE
DCOM- 20000928
LR  - 20220316
IS  - 1351-5101 (Print)
IS  - 1351-5101 (Linking)
VI  - 7
IP  - 4
DP  - 2000 Jul
TI  - Randomized controlled trial of brain-derived neurotrophic factor in 
      Guillain-Barre syndrome: a pilot study.
PG  - 423-6
AB  - Brain-derived neurotrophic factor (BDNF) has the theoretical potential to protect 
      neurones from axonal degeneration. The objective of this study was to discover 
      whether brain-derived neurotrophic factor is safe in Guillain-Barre syndrome, and 
      to make preliminary observations of its efficacy. This was a parallel group 
      randomized controlled trial of subcutaneous brain-derived neurotrophic factor 25 
      microg/kg daily compared with placebo for up to 24 weeks or until patients could 
      walk without aid. Six patients received brain-derived neurotrophic factor, of 
      whom three had serious adverse events including one death. Four patients received 
      placebo, of whom two had serious adverse events including one death. The rate and 
      extent of recovery were similar in the two groups. This pilot study did not 
      detect any serious adverse events attributed to brain-derived neurotrophic factor 
      treatment.
FAU - Bensa, S
AU  - Bensa S
AD  - Department of Neuroimmunology, Guy's, King's and St Thomas' School of Medicine, 
      Guy's Hospital, London, UK.
FAU - Hadden, R D
AU  - Hadden RD
FAU - Hahn, A
AU  - Hahn A
FAU - Hughes, R A
AU  - Hughes RA
FAU - Willison, H J
AU  - Willison HJ
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*administration & dosage/*adverse effects
MH  - Disease Progression
MH  - Female
MH  - Guillain-Barre Syndrome/*drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Treatment Outcome
EDAT- 2000/09/06 11:00
MHDA- 2000/09/30 11:01
CRDT- 2000/09/06 11:00
PHST- 2000/09/06 11:00 [pubmed]
PHST- 2000/09/30 11:01 [medline]
PHST- 2000/09/06 11:00 [entrez]
AID - ene096 [pii]
AID - 10.1046/j.1468-1331.2000.00096.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2000 Jul;7(4):423-6. doi: 10.1046/j.1468-1331.2000.00096.x.