PMID- 10971726
OWN - NLM
STAT- MEDLINE
DCOM- 20001019
LR  - 20220331
IS  - 0011-9059 (Print)
IS  - 0011-9059 (Linking)
VI  - 39
IP  - 8
DP  - 2000 Aug
TI  - HLA in alopecia areata.
PG  - 589-92
AB  - BACKGROUND: The aim of this study was to investigate the human leukocyte antigen 
      (HLA) characteristics of Turkish alopecia areata patients, and the correlation of 
      the HLA profile with age of onset, severity and duration of the disease, presence 
      of ophiasis, and family history. METHODS: A total of 88 patients with alopecia 
      areata, alopecia totalis, or alopecia universalis were compared with 100 healthy 
      controls. HLA typing was performed by the Terasaki microlymphocytotoxicity 
      method. RESULTS: The frequency of HLA-A1, HLA-B62(15), HLA-DQ1, and HLA-DQ3 was 
      significantly higher in patients than in controls. HLA-DR16 was significantly 
      less common in patients than in the control group, and we concluded that this 
      allele might have a protective role for alopecia areata. Juvenile onset and 
      severe involvement were related with HLA-Cw7 and HLA-DR1, respectively. The HLA 
      profile was independent of the existence of long-standing disease, presence of 
      ophiasis, and a positive family history. CONCLUSIONS: In HLA-alopecia areata 
      association, ethnic differences may play a role.
FAU - Kavak, A
AU  - Kavak A
AD  - Departments of Dermatology and Medical Biology, Medical Faculty, Istanbul 
      University, Istanbul, Turkey. ays_kavak@excite.com
FAU - Baykal, C
AU  - Baykal C
FAU - Ozarmagan, G
AU  - Ozarmagan G
FAU - Akar, U
AU  - Akar U
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Alleles
MH  - Alopecia Areata/*genetics/*immunology
MH  - Case-Control Studies
MH  - Female
MH  - HLA Antigens/classification/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Severity of Illness Index
MH  - Turkey
EDAT- 2000/09/06 11:00
MHDA- 2000/10/21 11:01
CRDT- 2000/09/06 11:00
PHST- 2000/09/06 11:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/09/06 11:00 [entrez]
AID - ijd921 [pii]
AID - 10.1046/j.1365-4362.2000.00921.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2000 Aug;39(8):589-92. doi: 10.1046/j.1365-4362.2000.00921.x.