PMID- 10976082
OWN - NLM
STAT- MEDLINE
DCOM- 20001004
LR  - 20190503
IS  - 0003-4967 (Print)
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 59
IP  - 9
DP  - 2000 Sep
TI  - Predictive value of interleukin 1 gene polymorphisms for surgery.
PG  - 695-9
AB  - OBJECTIVES: To determine the influence of interleukin 1alpha (IL1alpha), IL1beta, 
      and IL1 receptor antagonist gene polymorphisms on disease outcome as assessed by 
      the need for major joint surgery within 15 years of diagnosis. PATIENTS AND 
      METHODS: 50 patients with rheumatoid arthritis (RA) who required major joint 
      surgery (hip, knee, or shoulder arthroplasty) within a 15 year period of disease 
      diagnosis and 50 patients with RA with disease duration greater than 15 years and 
      no major surgery were recruited together with 66 normal west of Scotland 
      controls. Genomic DNA and polymerase chain reaction were used to determine 
      polymorphisms in the genes for IL1alpha, IL1beta, and IL1 receptor antagonist. 
      For all patients with RA recruited to the study, HLA-DR beta1 gene status was 
      recorded as was the erythrocyte sedimentation rate (ESR) at the first ever clinic 
      visit. RESULTS: No difference in the allele frequencies or genotypes of the 
      IL1alpha and IL1 receptor antagonist gene polymorphisms was found between the 
      controls and patients with RA, with or without previous surgery. IL1beta allele 2 
      was overrepresented in patients with RA who had undergone surgery compared with 
      patients who had not (40% v 27%, chi(2)=4, 1df, p=0.04). ESR at the first ever 
      clinic visit was significantly higher in those carrying allele 2 (36 mm/1st h v 
      22 mm/1st h, p=0.04). When patients, with or without previous surgery, who did 
      not carry two disease associated HLA-DR beta1 alleles were compared, an increase 
      in allele 2 was observed in the surgery cohort (42% v 25%, chi(2)=4.8, 1df, 
      p=0.03). CONCLUSIONS: Patients who require major joint surgery were found to 
      carry the IL1beta allele 2 more often than expected. Patients with this allele 
      also had a higher initial ESR. This may be useful in predicting early surgery in 
      patients who do not carry two disease associated HLA-DR beta1 alleles. Although 
      these findings are interesting, further functional and epidemiological studies to 
      confirm these observations are required.
FAU - Crilly, A
AU  - Crilly A
AD  - University Department of Medicine, 10 Alexandra Parade, Glasgow Royal Infirmary, 
      Glasgow G31 2ER, UK.
FAU - Maiden, N
AU  - Maiden N
FAU - Capell, H A
AU  - Capell HA
FAU - Madhok, R
AU  - Madhok R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (IL1RN protein, human)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-1)
RN  - 0 (Sialoglycoproteins)
SB  - IM
CIN - Ann Rheum Dis. 2001 Jul;60(7):718-9. PMID: 11436858
MH  - Aged
MH  - Alleles
MH  - Arthritis, Rheumatoid/blood/*genetics/*surgery
MH  - Arthroplasty, Replacement
MH  - Blood Sedimentation
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/analysis
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Interleukin-1/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Prognosis
MH  - Retrospective Studies
MH  - Sialoglycoproteins/genetics
PMC - PMC1753257
EDAT- 2000/09/08 11:00
MHDA- 2000/10/07 11:01
PMCR- 2003/09/01
CRDT- 2000/09/08 11:00
PHST- 2000/09/08 11:00 [pubmed]
PHST- 2000/10/07 11:01 [medline]
PHST- 2000/09/08 11:00 [entrez]
PHST- 2003/09/01 00:00 [pmc-release]
AID - 10.1136/ard.59.9.695 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2000 Sep;59(9):695-9. doi: 10.1136/ard.59.9.695.