PMID- 10976389
OWN - NLM
STAT- MEDLINE
DCOM- 20001228
LR  - 20200825
IS  - 0304-4602 (Print)
IS  - 0304-4602 (Linking)
VI  - 29
IP  - 3
DP  - 2000 May
TI  - Minimal change nephrotic syndrome--a complex genetic disorder.
PG  - 351-6
AB  - INTRODUCTION: Minimal change nephrotic syndrome (MCNS) is the most common primary 
      nephrotic syndrome in childhood. While the pathogenesis of this disease is still 
      unknown, there is considerable evidence that it is an immune disease. This role 
      of genetic susceptibility in this disease is the subject of this review. METHODS: 
      Reported studies addressing potential genetic factors in MCNS were reviewed. 
      These factors included human leukocyte antigen (HLA) associations, genes involved 
      in the renin-angiotensin system and cytokines. RESULTS: Several authors have 
      reported the presence of familial clustering, human leukocyte antigen (HLA) 
      associations, and association with asthma and atopy, suggesting a genetic 
      susceptibility to the disease. Moreover, recent studies on the role of the renin 
      angiotensin system, cytokines and their respective receptors on the severity and 
      clinical course of the disease, have lent further support to the immunogenetic 
      basis of this disease. CONCLUSION: Knowledge of the genetic basis of MCNS may 
      have important therapeutic implications in this disease, in particular, the role 
      of cytokines and their respective receptors, including the influence of 
      environmental factors on their expression.
FAU - Gong, W K
AU  - Gong WK
AD  - Department of Paediatrics, National University of Singapore, Singapore.
FAU - Cheung, W
AU  - Cheung W
FAU - Yap, H K
AU  - Yap HK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Singapore
TA  - Ann Acad Med Singap
JT  - Annals of the Academy of Medicine, Singapore
JID - 7503289
RN  - 0 (Cytokines)
SB  - IM
MH  - Cytokines/genetics
MH  - Gene Expression
MH  - Genes, MHC Class I/genetics
MH  - Genes, MHC Class II/genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Nephrosis, Lipoid/*genetics
MH  - Renin-Angiotensin System/genetics
RF  - 89
EDAT- 2000/09/08 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/08 11:00
PHST- 2000/09/08 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/08 11:00 [entrez]
PST - ppublish
SO  - Ann Acad Med Singap. 2000 May;29(3):351-6.