PMID- 10978867
OWN - NLM
STAT- MEDLINE
DCOM- 20001019
LR  - 20220331
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 45
IP  - 1-2
DP  - 2000 Sep 29
TI  - Premorbid functioning versus duration of untreated psychosis in 1 year outcome in 
      first-episode psychosis.
PG  - 1-9
AB  - OBJECTIVE: This study examines 1year outcome in patients having first-episode 
      non-affective psychosis, with emphasis on Duration of Untreated Psychosis (DUP) 
      and premorbid functioning, in order to clarify how these factors interact. 
      METHOD: Forty-three consecutively admitted patients were all rated on the 
      Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of 
      Functioning Scale (GAF), both upon hospitalization and at 1year follow-up. In 
      addition, premorbid functioning, DUP, duration of hospitalization, and social 
      functioning were rated. RESULTS: Fifty-six per cent were in remission, 18% 
      suffered multiple relapses and 26% were continuously psychotic at 1 year 
      follow-up. Both poor premorbid functioning and long DUP are significantly 
      correlated with more negative symptoms and poorer global functioning at 
      follow-up. Long DUP is also significantly correlated with more positive symptoms. 
      Even when we control for other factors, including premorbid functioning and 
      gender, DUP is a strong predictor of outcome. To a limited degree premorbid 
      functioning and DUP interact, but DUP has an independent influence on outcome. 
      CONCLUSIONS: these findings strengthen the rationale for establishing health 
      service programs for early detection and treatment of first-onset psychosis
FAU - Larsen, T K
AU  - Larsen TK
AD  - Psychiatric Hospital of Rogaland, Armauer Hansensv. 20, Stavanger, Norway. 
      tklarsen@online.no
FAU - Moe, L C
AU  - Moe LC
FAU - Vibe-Hansen, L
AU  - Vibe-Hansen L
FAU - Johannessen, J O
AU  - Johannessen JO
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Follow-Up Studies
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*diagnosis/etiology/rehabilitation
MH  - Regression Analysis
MH  - Remission, Spontaneous
MH  - Schizophrenia/complications/diagnosis
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2000/09/09 11:00
MHDA- 2000/10/21 11:01
CRDT- 2000/09/09 11:00
PHST- 2000/09/09 11:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/09/09 11:00 [entrez]
AID - S0920-9964(99)00169-3 [pii]
AID - 10.1016/s0920-9964(99)00169-3 [doi]
PST - ppublish
SO  - Schizophr Res. 2000 Sep 29;45(1-2):1-9. doi: 10.1016/s0920-9964(99)00169-3.