PMID- 10980276
OWN - NLM
STAT- MEDLINE
DCOM- 20010222
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 404
IP  - 1-2
DP  - 2000 Sep 15
TI  - Influence of different histamine receptor agonists and antagonists on 
      apomorphine-induced licking behavior in rat.
PG  - 169-74
AB  - The effects of different histamine receptor agonists and antagonists on 
      apomorphine-induced licking behavior in rats were investigated. Subcutaneous 
      (s.c.) injection of various doses of apomorphine (0. 125-1.25 mg/kg) induced 
      licking. The licking response was counted by direct observation and recorded for 
      a 75-min period. Intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) 
      injection of the histamine H(1) or H(2) receptor agonist, HTMT 
      (6-[2-(4-imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl) heptanecarboxamide) 
      (50 and 100 microg per rat), or dimaprit (10 and 15 mg/kg, i.p.), respectively, 
      potentiated apomorphine-induced licking, while the histamine H(3) receptor 
      agonist, imetit (5 and 10 mg/kg, i.p.), reduced the licking response induced by 
      apomorphine. Pretreatment with various histamine receptor antagonists, 
      dexchlorpheniramine (30 and 40 mg/kg, i.p.), diphenhydramine (20, 30 and 40 
      mg/kg, i.p.), famotidine (30 and 40 mg/kg, s.c.) and ranitidine (20, 30 and 40 
      mg/kg), reduced apomorphine-induced licking, while thioperamide (5 and 10 mg/kg, 
      i.p.) potentiated the apomorphine effect. The effects of HTMT and dimaprit were 
      blocked by dexchlorpheniramine (20 mg/kg, i.p.) and famotidine (20 mg/kg, s.c.), 
      respectively. The inhibitory effect elicited by imetit on apomorphine-induced 
      licking behavior was also abolished in animals treated with thioperamide (2.5 
      mg/kg, i.p.). The results suggest that histaminergic mechanisms may be involved 
      in the modulation of apomorphine-induced licking behavior.
FAU - Farzin, D
AU  - Farzin D
AD  - Department of Pharmacology, Sari School of Medicine, Mazandaran University of 
      Medical Sciences, 48168, Sari, Iran. davood.farzin@planetaccess.com
FAU - Attarzadeh, M
AU  - Attarzadeh M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Dopamine Agonists)
RN  - 0 (Histamine Agonists)
RN  - 0 (Histamine Antagonists)
RN  - 0 (Imidazoles)
RN  - 0 (Piperidines)
RN  - 0 (Toluidines)
RN  - 103827-15-2 (6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide)
RN  - 3Q9Q0B929N (dexchlorpheniramine)
RN  - 3U6IO1965U (Chlorpheniramine)
RN  - 5QZO15J2Z8 (Famotidine)
RN  - 677MJ4VPZC (imetit)
RN  - 820484N8I3 (Histamine)
RN  - 884KT10YB7 (Ranitidine)
RN  - 8GTS82S83M (Diphenhydramine)
RN  - GYV9AM2QAG (Thiourea)
RN  - II4319BWUI (thioperamide)
RN  - N21FAR7B4S (Apomorphine)
RN  - ZZQ699148P (Dimaprit)
SB  - IM
MH  - Animals
MH  - Apomorphine/*pharmacology
MH  - Chlorpheniramine/pharmacology
MH  - Dimaprit/pharmacology
MH  - Diphenhydramine/pharmacology
MH  - Dopamine Agonists/pharmacology
MH  - Drug Interactions
MH  - Famotidine/pharmacology
MH  - Histamine/*analogs & derivatives/pharmacology
MH  - Histamine Agonists/*pharmacology
MH  - Histamine Antagonists/*pharmacology
MH  - Imidazoles/pharmacology
MH  - Male
MH  - Piperidines/pharmacology
MH  - Ranitidine/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stereotyped Behavior/*drug effects
MH  - Thiourea/*analogs & derivatives/pharmacology
MH  - Toluidines/pharmacology
EDAT- 2000/09/12 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/09/12 11:00
PHST- 2000/09/12 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/09/12 11:00 [entrez]
AID - S0014-2999(00)00608-7 [pii]
AID - 10.1016/s0014-2999(00)00608-7 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2000 Sep 15;404(1-2):169-74. doi: 10.1016/s0014-2999(00)00608-7.