PMID- 10980328
OWN - NLM
STAT- MEDLINE
DCOM- 20001031
LR  - 20190826
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 96
IP  - 1
DP  - 2000 Sep 25
TI  - Serum interleukin-18 levels are elevated in schizophrenia.
PG  - 75-80
AB  - Interleukin-18 (IL-18) is a recently discovered proinflammatory cytokine which 
      plays a pivotal role in T helper 1 (Th1) responses. IL-18 is produced by 
      macrophage-like cells, and inappropriate IL-18 production has been known to be 
      involved in immunological disturbances. Schizophrenia is a common disease whose 
      pathogenesis is still unclear; however, an activation of the inflammatory 
      response system, including the Th1 cytokine response, may be related to the 
      pathophysiology of schizophrenia. We measured the serum IL-18 levels of 66 
      schizophrenics and age- and sex-matched control subjects by using an ELISA assay. 
      We found significantly increased serum IL-18 levels in the schizophrenic patients 
      (P=0.0002). This finding supports the hypothesis that immune activation is 
      involved in the pathophysiology of schizophrenia.
FAU - Tanaka, K F
AU  - Tanaka KF
AD  - Department of Neuropsychiatry, Keio University, School of Medicine, 35 
      Shinanomachi, Shinjuku-ku, 160-8582, Tokyo, Japan. tanaka@med.keio.ac.jp
FAU - Shintani, F
AU  - Shintani F
FAU - Fujii, Y
AU  - Fujii Y
FAU - Yagi, G
AU  - Yagi G
FAU - Asai, M
AU  - Asai M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cytokines/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunity, Cellular
MH  - Interleukin-18/*blood/metabolism
MH  - Male
MH  - Middle Aged
MH  - Schizophrenia/*immunology/metabolism
MH  - T-Lymphocytes, Helper-Inducer/*immunology
EDAT- 2000/09/12 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/12 11:00
PHST- 2000/09/12 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/12 11:00 [entrez]
AID - S0165-1781(00)00196-7 [pii]
AID - 10.1016/s0165-1781(00)00196-7 [doi]
PST - ppublish
SO  - Psychiatry Res. 2000 Sep 25;96(1):75-80. doi: 10.1016/s0165-1781(00)00196-7.