PMID- 10980627
OWN - NLM
STAT- MEDLINE
DCOM- 20001211
LR  - 20091119
IS  - 0390-6078 (Print)
IS  - 0390-6078 (Linking)
VI  - 85
IP  - 9
DP  - 2000 Sep
TI  - Deletions at 11q23 in different lymphoma subtypes.
PG  - 908-12
AB  - BACKGROUND AND OBJECTIVES: Chromosome band 11q23 is frequently deleted in various 
      types of neoplasm. The region represented by yeast artificial chromosome (YAC) 
      clone 755b11 at 11q23 has been shown to be the minimal common region of deletion 
      in mantle cell lymphoma (MCL) and B-cell chronic lymphocytic leukemia (B-CLL). 
      The aim of the study was to determine the frequencies of 11q23 deletion in 
      different lymphoma subtypes. DESIGN AND METHODS: We performed fluorescence in 
      situ hybridization (FISH) analysis with YAC755b11 on either peripheral blood or 
      lymph node biopsy (LN) specimens of patients diagnosed as having MCL (47), 
      CLL/small lymphocytic lymphoma (SLL) (62), diffuse large cell lymphoma (DLCL) 
      (17), follicular lymphoma (FL) (9), and Hodgkin's disease (HD) (11). Fifteen 
      cases of reactive or normal lymph node biopsies were studied as controls. 
      RESULTS: Forty of the 161 (25%) samples exhibited deletions in the region 
      represented by YAC755b11. The 11q23 deletion was found only in MCL (23, 49%), CLL 
      / SLL (13, 21%) and DLCL (4, 24%). Three cases were classified as Richter's 
      syndrome and they all exhibited the deletion at 11q23. The deletion frequencies 
      in the blood specimens of typical CLL (30%) and lymph node specimens of CLL/SLL 
      (13%) were remarkably different. INTERPRETATION AND CONCLUSIONS: Our study 
      demonstrated that the 11q23 deletion is not common in lymphomas other than MCL, 
      CLL and DLCL. It also showed the possible correlation of the 11q23 deletion with 
      the transformation of localized lymphoma to CLL, and with the development of 
      Richter's syndrome.
FAU - Zhu, Y
AU  - Zhu Y
AD  - Department of Medical Genetics, Haartman Institute and Helsinki University 
      Central Hospital, University of Helsinki, Helsinki, Finland.
FAU - Monni, O
AU  - Monni O
FAU - Franssila, K
AU  - Franssila K
FAU - Elonen, E
AU  - Elonen E
FAU - Vilpo, J
AU  - Vilpo J
FAU - Joensuu, H
AU  - Joensuu H
FAU - Knuutila, S
AU  - Knuutila S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Chromosomes, Artificial, Yeast
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Cytogenetic Analysis
MH  - Female
MH  - Gene Deletion
MH  - Genetic Testing
MH  - Hodgkin Disease/genetics
MH  - Humans
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/genetics
MH  - Lymphoma/classification/*genetics
MH  - Lymphoma, Large B-Cell, Diffuse/genetics
MH  - Lymphoma, Mantle-Cell/genetics
MH  - Male
MH  - Middle Aged
EDAT- 2000/09/12 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/12 11:00
PHST- 2000/09/12 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/12 11:00 [entrez]
PST - ppublish
SO  - Haematologica. 2000 Sep;85(9):908-12.