PMID- 10980632
OWN - NLM
STAT- MEDLINE
DCOM- 20001211
LR  - 20161124
IS  - 0390-6078 (Print)
IS  - 0390-6078 (Linking)
VI  - 85
IP  - 9
DP  - 2000 Sep
TI  - Do the low molecular weight heparins improve efficacy and safety of the treatment 
      of deep venous thrombosis? A meta-analysis.
PG  - 935-42
AB  - BACKGROUND AND OBJECTIVES: We compared the efficacy and safety of low molecular 
      weight heparins (LMWH) and unfractionated heparin (UFH) in the treatement of deep 
      venous thrombosis (DVT). A comparison between two daily subcutaneous injections 
      of LMWH against a single injection was also performed. DESIGN AND METHODS: The 
      study was performed by a meta-analysis. Clot improvement in venography, 
      recurrency, total mortality and major hemorrhages were assessed in 4,472 patients 
      with DVT from 21 studies treated with subcutaneous LMWH or UFH. RESULTS: An 
      improvement in clot reduction (odds ratio 0.73, 95% confidence interval 0.59 to 
      0.90, p = 0.004), a decrease in total mortality (0. 68, 0.50 to 0.91, p = 0.012) 
      and a lower incidence of hemorrhage (0. 65, 0.43 to 0.98, p = 0.047) were 
      observed in LMWH treated patients. There were no differences in recurrences 
      (0.78, 0.59 to 1.04, p = 0. 10). A single dose of LMWH was better than two in 
      reducing major bleeding (c2 = 4.99, p = 0.025); however, the two dose regimen was 
      more effective in clot reduction (c2 = 8.56, p = 0.004). INTERPRETATION AND 
      CONCLUSIONS: LMWH is superior to UFH in terms of safety and efficacy. A single 
      daily dose of LMWH dose is a suitable therapeutic regimen and could facilitate 
      the outpatient treatment of venous thromboembolism.
FAU - Rocha, E
AU  - Rocha E
AD  - Hematology Service, University Clinic of Navarra, Avenida Pio XII s/n, P.O. 4209, 
      Pamplona, Spain. erocha@unav.es
FAU - Martinez-Gonzalez, M A
AU  - Martinez-Gonzalez MA
FAU - Montes, R
AU  - Montes R
FAU - Panizo, C
AU  - Panizo C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Hemorrhage/chemically induced
MH  - Heparin/standards/therapeutic use/toxicity
MH  - Heparin, Low-Molecular-Weight/standards/*therapeutic use/toxicity
MH  - Humans
MH  - Phlebography
MH  - Randomized Controlled Trials as Topic
MH  - Recurrence
MH  - Survival Rate
MH  - Thromboembolism/complications/diagnostic imaging/drug therapy
MH  - Venous Thrombosis/complications/diagnostic imaging/*drug therapy
EDAT- 2000/09/12 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/12 11:00
PHST- 2000/09/12 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/12 11:00 [entrez]
PST - ppublish
SO  - Haematologica. 2000 Sep;85(9):935-42.