PMID- 10981522
OWN - NLM
STAT- MEDLINE
DCOM- 20010126
LR  - 20191104
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 11
IP  - 3
DP  - 2000 Aug
TI  - Hyperimmunoglobulin-E syndrome with recurrent infection: a review of current 
      opinion and treatment.
PG  - 133-41
AB  - Hyperimmunoglobulin E (hyper-IgE) syndrome with recurrent infection is a rare 
      idiopathic primary immunodeficiency. It consists of a severe dermatitis with 
      recurrent abscess formation, respiratory tract infections and very high titres of 
      serum immunoglobulin E (IgE). Hyper-IgE syndrome is also associated with skeletal 
      abnormalities. Variability of presentation makes it easy to confuse the diagnosis 
      with that of severe atopy or other rare immunodeficiencies. The aim of this 
      article is to review the literature in order to consider the clinical findings, 
      etiology and treatment of this syndrome.
FAU - Erlewyn-Lajeunesse, M D
AU  - Erlewyn-Lajeunesse MD
AD  - Allergy and Inflammation Sciences Division (Child Health), School of Medicine, 
      University of Southampton, Southampton General Hospital, UK. mdsel@soton.ac.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
SB  - IM
MH  - Child
MH  - Chromosomes, Human, Pair 4
MH  - Female
MH  - Humans
MH  - Job Syndrome/genetics/pathology/*therapy
MH  - Male
MH  - Skin/pathology
RF  - 83
EDAT- 2000/09/12 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/12 11:00
PHST- 2000/09/12 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/12 11:00 [entrez]
AID - 10.1034/j.1399-3038.2000.00091.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2000 Aug;11(3):133-41. doi: 
      10.1034/j.1399-3038.2000.00091.x.