PMID- 10981656
OWN - NLM
STAT- MEDLINE
DCOM- 20010116
LR  - 20170214
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 9
IP  - 6
DP  - 2000
TI  - Parkinsonism as unusual neurological complication in childhood systemic lupus 
      erythematosus.
PG  - 474-7
AB  - Parkinsonism complicating systemic lupus erythematosus (SLE) is extremely rare. 
      We report two girls with SLE who developed extrapyramidal parkinsonian features 
      after an initial stormy course. One patient presented with generalized tonic 
      clonic seizure and was then noted to have akinetic mutism and masked face. MRI 
      brain revealed abnormal signals in bilateral basal ganglia and single photon 
      emission computed tomography (SPECT) showed hypoperfusion in the same area. EEG 
      background was slow and disorganized. Symptoms persisted despite high dose 
      intravenous methylprednisolone and cyclophosphamide. Intravenous immunoglobulin 
      (IVIG) was prescribed empirically and was followed by complete recovery. Both EEG 
      and MRI brain were normal on follow-up. The second patient was found unconscious 
      and then developed bradykinesia, mutism and shuffling gait. MRI and SPECT both 
      detected abnormalities in basal ganglia. EEG was slow. Intravenous immunoglobulin 
      was given after methylprednisolone and cyclophosphamide. This was followed by 
      clinical improvement. The pathogenesis of basal ganglia injury in SLE, along with 
      the management of cerebral lupus and the mechanisms of action of IVIG, are 
      discussed.
FAU - Kwong, K L
AU  - Kwong KL
AD  - Department of Paediatrics, Tuen Mun Hospital, Hong Kong, NT, SAR China.
FAU - Chu, R
AU  - Chu R
FAU - Wong, S N
AU  - Wong SN
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
SB  - IM
MH  - Child
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*complications/physiopathology
MH  - Parkinsonian Disorders/*etiology/physiopathology
EDAT- 2000/09/12 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/12 11:00
PHST- 2000/09/12 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/12 11:00 [entrez]
AID - 10.1191/096120300678828578 [doi]
PST - ppublish
SO  - Lupus. 2000;9(6):474-7. doi: 10.1191/096120300678828578.