PMID- 10982690
OWN - NLM
STAT- MEDLINE
DCOM- 20001103
LR  - 20191104
IS  - 0949-2658 (Print)
IS  - 0949-2658 (Linking)
VI  - 5
IP  - 4
DP  - 2000
TI  - Development of the bones and synovial joints in the rat model of the VATER 
      association.
PG  - 390-6
AB  - The adriamycin-induced rat model of the Vertebral, Anorectal, Tracheo-Esophageal, 
      Radial and Renal (VATER) association produces a variety of vertebral, rib, and 
      limb abnormalities. This study was designed to document accurately the nature of 
      these abnormalities and to determine whether synovial joints are affected. 
      Fetuses from pregnant Sprague Dawley rats that had received intraperitoneal 
      injections of 1.75 mg/kg of adriamycin on days 6-9 or 10-13 of gestation were 
      harvested. Double-stained skeletal preparations and histological sections were 
      examined for vertebral, rib, and limb anomalies. The incidence of anomalies was 
      high in the group treated on gestational days (GD) 6-9, while it was low in the 
      GD 10-13 group. The length and thickness of the long bones were reduced, with 
      bowing and reduction in their endochondral ossification. Sirenomelia occurred in 
      the group treated on GD 6-9, and was often associated with a short tail and anal 
      atresia. The joint cavities, and intra-articular structures such as menisci and 
      the cruciate ligaments developed normally from the mesenchymal interzone. These 
      data indicate that adriamycin inhibits skeletal growth and differentiation 
      without any interference in the differentiation of the mesenchymal interzone, 
      thus producing normal synovial joints.
FAU - Abu-Hijleh, G
AU  - Abu-Hijleh G
AD  - Department of Paediatric Surgery, Christchurch Hospital, Private Bag 4710, 
      Christchurch, New Zealand.
FAU - Qi, B Q
AU  - Qi BQ
FAU - Williams, A K
AU  - Williams AK
FAU - Beasley, S W
AU  - Beasley SW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Orthop Sci
JT  - Journal of orthopaedic science : official journal of the Japanese Orthopaedic 
      Association
JID - 9604934
RN  - 0 (Antineoplastic Agents)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Abnormalities, Multiple/*embryology/pathology
MH  - Animals
MH  - Antineoplastic Agents
MH  - Bone Diseases, Developmental/chemically induced/*embryology/pathology
MH  - Bone and Bones/*embryology/pathology
MH  - Doxorubicin
MH  - Ectromelia/embryology/pathology
MH  - Female
MH  - Humans
MH  - Joints/*embryology/pathology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Syndrome
MH  - Synovial Membrane/*embryology/pathology
EDAT- 2000/09/12 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/12 11:00
PHST- 2000/09/12 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/12 11:00 [entrez]
AID - S0949-2658(15)33469-2 [pii]
AID - 10.1007/pl00021455 [doi]
PST - ppublish
SO  - J Orthop Sci. 2000;5(4):390-6. doi: 10.1007/pl00021455.