PMID- 10984327
OWN - NLM
STAT- MEDLINE
DCOM- 20001211
LR  - 20061115
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 31 Suppl 2
DP  - 2000 Aug
TI  - Clinical pharmacology of the fluoroquinolones: studies in human dynamic/kinetic 
      models.
PG  - S40-4
AB  - Traditional antibiotic dosage adjustments, compensate only for disease-induced 
      changes in the serum concentration profile. Dosage adjustments tend to be 
      effective when a well-defined range of concentration is associated with efficacy. 
      However, the bacterial target of antibiotic action-minimum inhibitory 
      concentration (MIC) is variable, because even susceptible bacteria may differ 
      greatly in their antibiotic susceptibility. Newly developed computerized methods 
      for the quantitation of susceptibility allow for testing of integrated 
      kinetic-susceptibility models in patients. Our attention has focused on 
      fluoroquinolones, since they are relatively nontoxic and provide the necessary 
      dosage range needed to elucidate correlations between concentration and response. 
      Studies of patients with nosocomial gram-negative pneumonia reveal that the best 
      correlation parameters of favorable outcome are approximately 80% of time over 
      MIC and 24-h area under the time-concentration curve (AUC)-to-MIC values >125.
FAU - Schentag, J J
AU  - Schentag JJ
AD  - State University of New York at Buffalo School of Pharmacy, Millard Fillmore 
      Hospital, Buffalo, NY 14209, USA. jschenta@mfhs.edu.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Fluoroquinolones)
SB  - IM
MH  - Anti-Infective Agents/administration & dosage/*pharmacokinetics/*pharmacology
MH  - Cross Infection/drug therapy
MH  - Drug Resistance, Microbial
MH  - Fluoroquinolones
MH  - Gram-Negative Bacterial Infections/drug therapy
MH  - Humans
MH  - Microbial Sensitivity Tests
MH  - Models, Biological
MH  - Pneumonia, Bacterial/drug therapy
RF  - 21
EDAT- 2000/09/13 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/13 11:00
PHST- 2000/09/13 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/13 11:00 [entrez]
AID - CID991219 [pii]
AID - 10.1086/314059 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2000 Aug;31 Suppl 2:S40-4. doi: 10.1086/314059.