PMID- 10985938
OWN - NLM
STAT- MEDLINE
DCOM- 20001026
LR  - 20091119
VI  - 14
IP  - 4
DP  - 2000 Aug
TI  - New molecular techniques for chromosome analysis.
PG  - 677-90
AB  - The advent of molecular genetic technology has significantly advanced knowledge 
      about the structure of chromosomes and their behaviour during meiosis and 
      mitosis, as well as delineating cytogenetic aberrations that cannot be identified 
      by conventional chromosome analysis. Molecular cytogenetics, the visualization of 
      genetic loci using the dynamic recombinant technology of fluorescence in situ 
      hybridization (FISH), now provides the obstetrician and gynaecologist with 
      increasingly important diagnostic and prognostic information heretofore 
      unavailable. The technical principles underlying FISH are briefly discussed. 
      Emphasis is placed on the clinical applications of FISH and technologies derived 
      from FISH, in particular comparative genome hybridization, microdissection FISH 
      and multiplex FISH. These technologies play increasingly significant roles in 
      preimplantation and prenatal genetic diagnosis, in the identification of 
      microdeletion syndromes, cryptic translocations and marker chromosomes, and in 
      defining chromosome mosaicism. FISH and related technologies also constitute 
      essential diagnostic modalities in follow-up of organ transplantation, in a 
      variety of haematological disorders and in determining the amplification of 
      oncogenes associated with specific forms of cancer and neoplasia.
CI  - Copyright 2000 Harcourt Publishers Ltd.
FAU - Pergament, E
AU  - Pergament E
AD  - Northwestern University Medical School, Prentice Women's Hospital and Maternity 
      Center, 333 East Superior Street, Chicago, IL, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Baillieres Best Pract Res Clin Obstet Gynaecol
JT  - Bailliere's best practice & research. Clinical obstetrics & gynaecology
JID - 100890322
SB  - IM
MH  - Female
MH  - Fetal Diseases/*diagnosis
MH  - *Genetic Techniques
MH  - Genetic Testing/*methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Nucleic Acid Hybridization
MH  - Pregnancy
MH  - Prenatal Diagnosis/*methods
RF  - 38
EDAT- 2000/09/14 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/14 11:00
PHST- 2000/09/14 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/14 11:00 [entrez]
AID - beog.1999.0104 [pii]
AID - 10.1053/beog.1999.0104 [doi]
PST - ppublish
SO  - Baillieres Best Pract Res Clin Obstet Gynaecol. 2000 Aug;14(4):677-90. doi: 
      10.1053/beog.1999.0104.