PMID- 10989265
OWN - NLM
STAT- MEDLINE
DCOM- 20001101
LR  - 20220408
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 23
IP  - 4
DP  - 2000 Oct
TI  - 3,4-Methylenedioxymethamphetamine (MDMA) modulates cortical and limbic brain 
      activity as measured by [H(2)(15)O]-PET in healthy humans.
PG  - 388-95
AB  - [H(2)(15)O]-Positron Emission Tomography (PET) was used to examine regional 
      cerebral blood flow (rCBF) after administration of a single oral dose of the 
      serotonin realeaser and uptake inhibitor MDMA (1.7 mg/kg) or placebo to 16 
      MDMA-naive subjects. Psychological changes were assessed by psychometric rating 
      scales. MDMA produced distributed changes in regional blood flow including 
      increases in ventromedial frontal and occipital cortex, inferior temporal lobe 
      and cerebellum; and decreases in the motor and somatosensory cortex, temporal 
      lobe including left amygdala, cingulate cortex, insula and thalamus. Concomitant 
      with these changes, subjects experienced heightened mood, increased extroversion, 
      slight derealization and mild perceptual alterations. MDMA also produced 
      increases in blood pressure and several side effects such as jaw clenching, lack 
      of appetite and difficulty concentrating. These results indicate that a 
      distributed cluster of brain areas underlie the various effects of MDMA in 
      humans.
FAU - Gamma, A
AU  - Gamma A
AD  - University Hospital of Psychiatry Zurich, PO Box 68, 8029, Zurich, Switzerland.
FAU - Buck, A
AU  - Buck A
FAU - Berthold, T
AU  - Berthold T
FAU - Liechti, M E
AU  - Liechti ME
FAU - Vollenweider, F X
AU  - Vollenweider FX
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Serotonin Agents)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
EIN - Neuropsychopharmacology 2000 Nov;23(5):following 598. Hell, D [corrected to 
      Liechti, ME]
MH  - Adult
MH  - Affect/*drug effects/physiology
MH  - Analysis of Variance
MH  - Blood Pressure/drug effects/physiology
MH  - Brain/blood supply/diagnostic imaging/*drug effects
MH  - Cerebrovascular Circulation/*drug effects
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Psychometrics
MH  - Regional Blood Flow/drug effects
MH  - Serotonin Agents/*pharmacology
MH  - *Tomography, Emission-Computed
EDAT- 2000/09/16 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/16 11:00
PHST- 2000/09/16 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/16 11:00 [entrez]
AID - S0893133X00001305 [pii]
AID - 10.1016/S0893-133X(00)00130-5 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2000 Oct;23(4):388-95. doi: 
      10.1016/S0893-133X(00)00130-5.