PMID- 10989646
OWN - NLM
STAT- MEDLINE
DCOM- 20000928
LR  - 20190513
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 114
IP  - 3
DP  - 2000 Sep
TI  - The relationship between typical and atypical B-cell chronic lymphocytic 
      leukemia. A comparative genomic hybridization-based study.
PG  - 448-58
AB  - B-cell chronic lymphocytic leukemia (CLL) can be classified as typical or 
      atypical based on morphologic and immunophenotypic features. The relationship 
      between these 2 groups is uncertain, and there is some evidence they may be 
      different entities. We used comparative genomic hybridization (CGH) to explore 
      the cytogenetic relationship between typical and atypical B-cell CLL. Results 
      showed a similar pattern of chromosome gains and losses detected in typical and 
      atypical B-cell CLL, suggesting they are related disorders. Gain on chromosome 12 
      material occurred in cases that were apparently normal by interphase fluorescence 
      in situ hybridization (FISH). The common region mapped to chromosome 12q21. Gains 
      on chromosome 4 were present in 74% (32) of cases analyzed and were confirmed by 
      interphase FISH in 30% (13) of cases. We previously have shown the strong 
      association between trisomy 12 as detected by FISH and CD11a expression in 
      atypical B-cell CLL. In the present study, CGH demonstrated additional gains on 
      12p and 12q outside the common amplified region of 12q21 in these patients.
FAU - O'Connor, S J
AU  - O'Connor SJ
AD  - Haematological Malignancy Diagnostic Service, General Infirmary at Leeds, 
      England.
FAU - Su'ut, L
AU  - Su'ut L
FAU - Morgan, G J
AU  - Morgan GJ
FAU - Jack, A S
AU  - Jack AS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 12
MH  - Chromosomes, Human, Pair 4
MH  - DNA, Neoplasm/*analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization
MH  - Trisomy
EDAT- 2000/09/16 11:00
MHDA- 2000/09/30 11:01
CRDT- 2000/09/16 11:00
PHST- 2000/09/16 11:00 [pubmed]
PHST- 2000/09/30 11:01 [medline]
PHST- 2000/09/16 11:00 [entrez]
AID - 10.1093/ajcp/114.3.448 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2000 Sep;114(3):448-58. doi: 10.1093/ajcp/114.3.448.