PMID- 10992527
OWN - NLM
STAT- MEDLINE
DCOM- 20001103
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 68
IP  - 10
DP  - 2000 Oct
TI  - Enterotoxin-specific immunoglobulin E responses in humans after infection or 
      vaccination with diarrhea-causing enteropathogens.
PG  - 6077-81
AB  - Cholera toxin (CT)-specific antibody responses of the immunoglobulin E (IgE) 
      isotype in the sera of adult patients suffering from infection with either Vibrio 
      cholerae O1, V. cholerae O139, or enterotoxigenic Escherichia coli (ETEC) were 
      analyzed and compared with those in the sera of volunteers immunized with a 
      bivalent B subunit O1/O139 whole-cell cholera vaccine. A significant IgE response 
      to CT was observed in 90% of the patients with V. cholerae O1 infection (18 of 
      20; P = <0.001) and 95% of the patients with V. cholerae O139 infection (19 of 
      20; P = <0.001). Similarly, the majority of the patients with ETEC diarrhea (83%; 
      13 of 15) showed a positive IgE response to CT. Eight of 10 North American 
      volunteers (80%) orally challenged with V. cholerae O1 showed CT-specific IgE 
      responses (P = 0.004). In contrast, Swedish volunteers immunized with the oral 
      cholera vaccine showed no IgE responses to CT (P value not significant). During 
      the study period, total IgE levels in the sera of the diarrheal patients, the 
      North American volunteers, and the Swedish cholera vaccinees alike remained 
      unchanged. However, the total IgE levels in the sera of patients and healthy 
      Bangladeshi controls were on average 89-fold higher than those in the sera of the 
      healthy Swedish volunteers and 34-fold higher than those in the sera of the North 
      American volunteers.
FAU - Qadri, F
AU  - Qadri F
AD  - International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, 
      Bangladesh. fqadri@icddrb.org
FAU - Asaduzzaman, M
AU  - Asaduzzaman M
FAU - Wenneras, C
AU  - Wenneras C
FAU - Mohi, G
AU  - Mohi G
FAU - Albert, M J
AU  - Albert MJ
FAU - Abdus Salam, M
AU  - Abdus Salam M
FAU - Sack, R B
AU  - Sack RB
FAU - Jertborn, M
AU  - Jertborn M
FAU - McGhee, J R
AU  - McGhee JR
FAU - Sack, D A
AU  - Sack DA
FAU - Holmgren, J
AU  - Holmgren J
LA  - eng
GR  - N01-AI 45252/AI/NIAID NIH HHS/United States
GR  - RR-00035/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Cholera Vaccines)
RN  - 0 (Enterotoxins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Bacterial/blood
MH  - Cholera/*immunology/microbiology
MH  - Cholera Vaccines/*administration & dosage
MH  - Enterotoxins/*immunology
MH  - Escherichia coli/immunology/metabolism
MH  - Escherichia coli Infections/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Vaccination
MH  - Vibrio cholerae/immunology
PMC - PMC101579
EDAT- 2000/09/19 11:00
MHDA- 2001/02/28 10:01
PMCR- 2000/10/01
CRDT- 2000/09/19 11:00
PHST- 2000/09/19 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/19 11:00 [entrez]
PHST- 2000/10/01 00:00 [pmc-release]
AID - 0270 [pii]
AID - 10.1128/IAI.68.10.6077-6081.2000 [doi]
PST - ppublish
SO  - Infect Immun. 2000 Oct;68(10):6077-81. doi: 10.1128/IAI.68.10.6077-6081.2000.