PMID- 10993274
OWN - NLM
STAT- MEDLINE
DCOM- 20001002
LR  - 20190921
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 437
IP  - 2
DP  - 2000 Aug
TI  - Collagen alteration in vascular remodeling by hemodynamic factors.
PG  - 138-48
AB  - The collagen alterations in the vascular wall remodeled by hemodynamic change 
      were investigated by electron microscopy and immunohistochemistry. The left 
      anterior descending coronary artery (LAD) without a myocardial bridge (MB) showed 
      both lower matrix metalloproteinase-1 (MMP-1) expression and a smaller extent of 
      spiraled collagen (SC) distribution than the LAD wall with MB, in which the 
      intima was influenced by high shear stress. In the wall of the varicose great 
      saphenous vein (GSV) the expression of MMP-1 was lower, while the expression of 
      prolyl 4-hydroxylase was higher, than in the normal GSV. The extent of SC 
      distribution in the intima and media of the varicose GSV was smaller than that in 
      the normal GSV. An analogous difference in results was demonstrated between the 
      portal vein (PV) of patients with liver cirrhosis and normal PV. However, the 
      levels of expression of MMP-2, MMP-9 and tissue inhibitors of MMP (TIMPs) in 
      these pathologic vessels were not different from those in the corresponding 
      normal vessels. The results indicate that hemodynamic forces such as shear stress 
      and increased intravascular blood pressure contribute to the collagen alterations 
      in the vascular wall, which may lead to vascular wall remodeling.
FAU - Ishikawa, Y
AU  - Ishikawa Y
AD  - Department of Pathology, Toho University School of Medicine, Tokyo, Japan.
FAU - Asuwa, N
AU  - Asuwa N
FAU - Ishii, T
AU  - Ishii T
FAU - Ito, K
AU  - Ito K
FAU - Akasaka, Y
AU  - Akasaka Y
FAU - Masuda, T
AU  - Masuda T
FAU - Zhang, L
AU  - Zhang L
FAU - Kiguchi, H
AU  - Kiguchi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - 9007-34-5 (Collagen)
RN  - EC 1.14.11.2 (Procollagen-Proline Dioxygenase)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Arteries/physiology/ultrastructure
MH  - Arteriosclerosis/pathology/physiopathology
MH  - Blood Vessels/*physiology/ultrastructure
MH  - Collagen/*metabolism
MH  - Coronary Vessels/physiology/ultrastructure
MH  - Female
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Matrix Metalloproteinases/metabolism
MH  - Microscopy, Electron
MH  - Middle Aged
MH  - Portal Vein/physiology/ultrastructure
MH  - Procollagen-Proline Dioxygenase/metabolism
MH  - Reference Values
MH  - Saphenous Vein/physiology/ultrastructure
MH  - Tissue Inhibitor of Metalloproteinases/metabolism
MH  - Varicose Veins/pathology/physiopathology
EDAT- 2000/09/19 11:00
MHDA- 2000/10/07 11:01
CRDT- 2000/09/19 11:00
PHST- 2000/09/19 11:00 [pubmed]
PHST- 2000/10/07 11:01 [medline]
PHST- 2000/09/19 11:00 [entrez]
AID - 10.1007/s004280000200 [doi]
PST - ppublish
SO  - Virchows Arch. 2000 Aug;437(2):138-48. doi: 10.1007/s004280000200.