PMID- 10995859
OWN - NLM
STAT- MEDLINE
DCOM- 20001018
LR  - 20191210
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 20
IP  - 18
DP  - 2000 Sep 15
TI  - Involvement of brain-derived neurotrophic factor in spatial memory formation and 
      maintenance in a radial arm maze test in rats.
PG  - 7116-21
AB  - Brain-derived neurotrophic factor (BDNF) regulates both short-term synaptic 
      functions and activity-dependent synaptic plasticity such as long-term 
      potentiation. In the present study, we investigated the role of BDNF in the 
      spatial reference and working memory in a radial arm maze test. The radial arm 
      maze training resulted in a significant increase in the BDNF mRNA expression in 
      the hippocampus, although the expression in the frontal cortex did not change. 
      When spatial learning was inhibited by treatment with 7-nitroindazole, an 
      inhibitor of brain nitric oxide synthase, the increase in the hippocampal BDNF 
      mRNA did not occur. To clarify the causal relation between BDNF mRNA expression 
      and spatial memory formation, we examined the effects of antisense BDNF treatment 
      on spatial learning and memory. A continuous intracerebroventricular infusion of 
      antisense BDNF oligonucleotide resulted in an impairment of spatial learning, 
      although the sense oligonucleotide had no effect. Treatment with antisense, but 
      not sense, BDNF oligonucleotide was associated with a significant reduction of 
      BDNF mRNA and protein levels in the hippocampus. Furthermore, treatment with 
      antisense BDNF oligonucleotide in rats, which had previously acquired spatial 
      memory by an extensive training, impaired both reference and working memory. 
      There were no differences in locomotor activity, food consumption, and body 
      weight between the antisense and sense oligonucleotide-treated rats. These 
      results suggest that BDNF plays an important role not only in the formation, but 
      also in the retention and/or recall, of spatial memory.
FAU - Mizuno, M
AU  - Mizuno M
AD  - Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University 
      Graduate School of Medicine, Showa-ku Nagoya 466-8560, Japan.
FAU - Yamada, K
AU  - Yamada K
FAU - Olariu, A
AU  - Olariu A
FAU - Nawa, H
AU  - Nawa H
FAU - Nabeshima, T
AU  - Nabeshima T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Indazoles)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (RNA, Messenger)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - UX0N37CMVH (7-nitroindazole)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/antagonists & inhibitors/genetics/*metabolism
MH  - Eating/drug effects
MH  - Frontal Lobe/metabolism
MH  - Hippocampus/metabolism
MH  - Indazoles/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Maze Learning/drug effects/*physiology
MH  - Motor Activity/drug effects
MH  - Nitric Oxide Synthase/antagonists & inhibitors
MH  - Oligonucleotides, Antisense/administration & dosage
MH  - RNA, Messenger/antagonists & inhibitors/biosynthesis
MH  - Rats
MH  - Rats, Wistar
MH  - Retention, Psychology/drug effects/*physiology
MH  - Spatial Behavior/drug effects/*physiology
PMC - PMC6772840
EDAT- 2000/09/21 11:00
MHDA- 2000/10/21 11:01
PMCR- 2001/03/15
CRDT- 2000/09/21 11:00
PHST- 2000/09/21 11:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/09/21 11:00 [entrez]
PHST- 2001/03/15 00:00 [pmc-release]
AID - 20/18/7116 [pii]
AID - 4536 [pii]
AID - 10.1523/JNEUROSCI.20-18-07116.2000 [doi]
PST - ppublish
SO  - J Neurosci. 2000 Sep 15;20(18):7116-21. doi: 10.1523/JNEUROSCI.20-18-07116.2000.