PMID- 10996284
OWN - NLM
STAT- MEDLINE
DCOM- 20010208
LR  - 20190831
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 72
IP  - 3
DP  - 2000 Oct
TI  - Effect of Vitex rotundifolia on immediate-type allergic reaction.
PG  - 443-50
AB  - We investigated the effect of aqueous extract of Vitex rotundifolia (L.) 
      (Verbenaceae) fruits (VRFE) on the immediate-type allergic reactions in vivo and 
      in vitro. VRFE (10(-4)-1.0 g/kg) dose-dependently inhibited systemic allergic 
      reaction induced by compound 48/80. When VRFE was employed in a systemic allergic 
      reaction test, the plasma histamine levels were reduced in a dose-dependent 
      manner. VRFE (5x10(-1) and 1.0 g/kg) inhibited passive cutaneous anaphylaxis 
      activated by anti-dinitrophenyl (DNP) IgE. VRFE (10(-3)-1.0 mg/ml) also 
      dose-dependently inhibited the histamine release from the rat peritoneal mast 
      cells (RPMC) by compound 48/80 or anti-DNP IgE. Moreover, VRFE (10(-3) mg/ml) had 
      a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis 
      factor-alpha production from RPMC. These results suggest that VRFE may be 
      beneficial in the regulation of immediate-type allergic reaction.
FAU - Shin, T Y
AU  - Shin TY
AD  - College of Pharmacy, Woosuk University, Wanju, 565-701, Chonbuk, South Korea.
FAU - Kim, S H
AU  - Kim SH
FAU - Lim, J P
AU  - Lim JP
FAU - Suh, E S
AU  - Suh ES
FAU - Jeong, H J
AU  - Jeong HJ
FAU - Kim, B D
AU  - Kim BD
FAU - Park, E J
AU  - Park EJ
FAU - Hwang, W J
AU  - Hwang WJ
FAU - Rye, D G
AU  - Rye DG
FAU - Baek, S H
AU  - Baek SH
FAU - An, N H
AU  - An NH
FAU - Kim, H M
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Histamine Release/drug effects
MH  - *Hypersensitivity, Immediate
MH  - Lamiaceae/*chemistry
MH  - Male
MH  - Mast Cells/drug effects/immunology
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 2000/09/21 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/09/21 11:00
PHST- 2000/09/21 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/09/21 11:00 [entrez]
AID - S0378874100002580 [pii]
AID - 10.1016/s0378-8741(00)00258-0 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2000 Oct;72(3):443-50. doi: 10.1016/s0378-8741(00)00258-0.