PMID- 10998535
OWN - NLM
STAT- MEDLINE
DCOM- 20001130
LR  - 20231213
IS  - 0196-9781 (Print)
IS  - 0196-9781 (Linking)
VI  - 21
IP  - 7
DP  - 2000 Jul
TI  - Nociceptin and the micturition reflex.
PG  - 1007-21
AB  - The i.v. administration of nociceptin (10-100 nmol/kg) inhibits the micturition 
      reflex in a naloxone-resistant manner. The effects induced by i.v. nociceptin 
      were not observed in capsaicin-pretreated animals indicating that i.v. nociceptin 
      inhibits the micturition reflex by inhibiting afferent discharge from 
      capsaicin-sensitive nerves. Supporting this interpretation, nociceptin also 
      inhibited the reflex but not the local bladder contraction induced by topical 
      capsaicin and protects this reflex (but not the local contraction) by 
      desensitization. Intrathecal nociceptin (10 nmol/rat) produces urodynamic 
      modifications similar to those induced by the i.v. administration. 
      Intracerebroventricular (i.c.v.) administration of nociceptin (0.3-1 nmol/rat) 
      also inhibited the micturition reflex in a naloxone-resistant manner suggesting a 
      direct effect on supraspinal sites controlling the micturition. Beyond the 
      inhibitory effects exerted by nociceptin on the micturition reflex, a peripheral 
      excitatory effect mediated by capsaicin-sensitive fibers was also detected. The 
      application of nociceptin (5-50 nmol/rat) onto the bladder serosa when the 
      intravesical volume was subthreshold for the triggering of the micturition 
      reflex, activated the reflex in a dose-dependent manner; the same treatment 
      produced a biphasic effect on the ongoing reflex. In addition to the triggering 
      of micturition reflex, topical nociceptin evokes a local tonic-type contraction 
      that was abolished by the coadministration of tachykinin NK(1) and NK(2) receptor 
      antagonists. Altogether these results indicate that ORL(1) receptors are present 
      at several sites for the integration of the micturition reflex, and that their 
      activation may produce both excitatory or inhibitory effects, depending on the 
      route of administration and the experimental conditions.
FAU - Lecci, A
AU  - Lecci A
AD  - Pharmacology Department, Menarini Ricerche, via Sette Santi 3, 50131, Florence, 
      Italy.
FAU - Giuliani, S
AU  - Giuliani S
FAU - Meini, S
AU  - Meini S
FAU - Maggi, C A
AU  - Maggi CA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Opioid Peptides)
RN  - 0 (Receptors, Opioid)
RN  - 0 (Receptors, Tachykinin)
RN  - 0 (Vasodilator Agents)
RN  - S07O44R1ZM (Capsaicin)
RN  - 0 (Nociceptin Receptor)
RN  - 0 (Oprl protein, rat)
SB  - IM
MH  - Animals
MH  - Capsaicin/pharmacology
MH  - Central Nervous System/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Injections, Intravenous
MH  - Injections, Spinal
MH  - Kinetics
MH  - Models, Biological
MH  - Nervous System/*drug effects
MH  - Opioid Peptides/administration & dosage/*metabolism/*pharmacology
MH  - Rats
MH  - Receptors, Opioid/metabolism
MH  - Receptors, Tachykinin/antagonists & inhibitors
MH  - Reflex/*drug effects
MH  - Spinal Cord/drug effects/metabolism
MH  - Time Factors
MH  - Urinary Bladder/*drug effects
MH  - Vasodilator Agents/pharmacology
MH  - Nociceptin Receptor
MH  - Nociceptin
RF  - 92
EDAT- 2000/09/22 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/22 11:00
PHST- 2000/09/22 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/22 11:00 [entrez]
AID - S0196-9781(00)00241-2 [pii]
AID - 10.1016/s0196-9781(00)00241-2 [doi]
PST - ppublish
SO  - Peptides. 2000 Jul;21(7):1007-21. doi: 10.1016/s0196-9781(00)00241-2.