PMID- 10999552
OWN - NLM
STAT- MEDLINE
DCOM- 20000926
LR  - 20190813
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 41
IP  - 9
DP  - 2000 Sep
TI  - Early and late intracortical inhibition in juvenile myoclonic epilepsy.
PG  - 1129-38
AB  - PURPOSE: We investigated 15 patients with juvenile myoclonic epilepsy (JME) by 
      subjecting them to single and paired transcranial magnetic stimulation to test 
      the hypothesis that motor cortical inhibition may be abnormal in this form of 
      benign epilepsy. METHODS: Different conditioning paradigms of paired transcranial 
      magnetic stimulation were used with interstimulus intervals (ISIs) of varying 
      lengths (1 to 400 milliseconds) to investigate changes in balance between 
      excitatory and inhibitory intracortical circuits. RESULTS: Motor evoked potential 
      (MEP) inhibition at ISIs of 1 to 4 milliseconds was significantly lower in JME 
      patients than in age-matched healthy controls (p < 0.001), whereas no significant 
      differences in MEP inhibition were noted at long ISIs (100 to 150 milliseconds). 
      This pattern was observed in both hemispheres in seven of seven patients studied 
      bilaterally and was present in both treated and untreated patients. There were no 
      group differences between JME patients and controls in intracortical 
      facilitation, motor threshold, MEP amplitude, and cortical silent period. 
      CONCLUSIONS: We documented a different pattern of MEP inhibition in JME patients, 
      suggesting impaired functioning of inhibitory interneuronal circuits, which may 
      account for the hyperexcitability of the motor system in this form of epilepsy.
FAU - Manganotti, P
AU  - Manganotti P
AD  - Dipartimento di Scienze Neurologiche e della Visione, University of Verona, 
      Italy.
FAU - Bongiovanni, L G
AU  - Bongiovanni LG
FAU - Zanette, G
AU  - Zanette G
FAU - Fiaschi, A
AU  - Fiaschi A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Adult
MH  - Epilepsies, Myoclonic/*diagnosis/physiopathology
MH  - Evoked Potentials/*physiology
MH  - Female
MH  - Humans
MH  - *Magnetics
MH  - Male
MH  - Motor Cortex/*physiology/physiopathology
MH  - Neural Inhibition/*physiology
MH  - Neural Pathways/physiology
MH  - gamma-Aminobutyric Acid/physiology
EDAT- 2000/09/22 11:00
MHDA- 2000/09/30 11:01
CRDT- 2000/09/22 11:00
PHST- 2000/09/22 11:00 [pubmed]
PHST- 2000/09/30 11:01 [medline]
PHST- 2000/09/22 11:00 [entrez]
AID - 10.1111/j.1528-1157.2000.tb00318.x [doi]
PST - ppublish
SO  - Epilepsia. 2000 Sep;41(9):1129-38. doi: 10.1111/j.1528-1157.2000.tb00318.x.