PMID- 10999790
OWN - NLM
STAT- MEDLINE
DCOM- 20001016
LR  - 20111117
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 85
IP  - 9
DP  - 2000 Sep
TI  - Carbohydrate-induced hypertriglyceridemia: an insight into the link between 
      plasma insulin and triglyceride concentrations.
PG  - 3085-8
AB  - This study was initiated to test the hypothesis that endogenous 
      hypertriglyceridemia results from a defect in the ability of insulin to inhibit 
      the release of very low-density lipoprotein-triglyceride (TG) from the liver. To 
      accomplish this goal, plasma glucose, insulin, free fatty acid (FFA), and TG 
      concentrations were compared in 12 healthy volunteers, in response to diets 
      containing either 40% or 60% of total calories as carbohydrate (CHO). The protein 
      content of the two diets was similar (15% of calories), and the fat content 
      varied inversely with the amount of CHO (45% or 25%). The diets were consumed in 
      random order, and measurements were made of plasma glucose, insulin, FFA, and TG 
      concentrations at the end of each dietary period, fasting, and at hourly 
      intervals following breakfast and lunch. The results indicated that the 60% CHO 
      diet resulted in higher fasting plasma TG concentrations associated with higher 
      day-long plasma insulin and TG concentrations, and lower FFA concentrations. 
      These results do not support the view that hypertriglyceridemia is secondary to a 
      failure of insulin to inhibit hepatic TG secretion.
FAU - McLaughlin, T
AU  - McLaughlin T
AD  - Department of Medicine, Stanford University School of Medicine, California 94305, 
      USA.
FAU - Abbasi, F
AU  - Abbasi F
FAU - Lamendola, C
AU  - Lamendola C
FAU - Yeni-Komshian, H
AU  - Yeni-Komshian H
FAU - Reaven, G
AU  - Reaven G
LA  - eng
GR  - HL-08506/HL/NHLBI NIH HHS/United States
GR  - RR-00070/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Diet
MH  - Dietary Carbohydrates/*metabolism
MH  - Double-Blind Method
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Humans
MH  - Hyperinsulinism/blood
MH  - Hypertriglyceridemia/*blood
MH  - Insulin/*blood
MH  - Male
MH  - Middle Aged
MH  - Triglycerides/*blood
EDAT- 2000/09/22 11:00
MHDA- 2000/10/21 11:01
CRDT- 2000/09/22 11:00
PHST- 2000/09/22 11:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/09/22 11:00 [entrez]
AID - 10.1210/jcem.85.9.6838 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2000 Sep;85(9):3085-8. doi: 10.1210/jcem.85.9.6838.