PMID- 11000490
OWN - NLM
STAT- MEDLINE
DCOM- 20010201
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 81
IP  - 1-2
DP  - 2000 Sep 30
TI  - Capsaicin effects on brain-derived neurotrophic factor in rat dorsal root ganglia 
      and spinal cord.
PG  - 181-6
AB  - The effects of capsaicin systemically administered in adult rats, with the major 
      focus on the expression of brain-derived neurotropic factor (BDNF) and its mRNA 
      in the dorsal root ganglion (DRG) and spinal cord, has been investigated by means 
      of immunohistochemistry and reverse transcriptase-polymerase chain reactions. The 
      percentage of BDNF-immunoreactive neurons in the L5 DRG was found to increase 
      significantly 1 day after capsaicin injection. Subsequently, it decreased slowly 
      returning to near normal levels 1 week later. Four weeks post-injection, a 
      significant reduction to below normal levels was observed. The temporal pattern 
      of BDNF mRNA expression in the DRG was similar to BDNF-immunoreactivity. In the 
      spinal cord, 1 and 3 days post-injection, no changes in the expression of the 
      BDNF-immunoreactive axonal fibers was noted. However, the expression had 
      decreased significantly after 1 and 4 weeks. The mechanism by which capsaicin 
      induces changes in expression of BDNF in DRG neurons and the functional 
      significance of the rapid increase in BDNF levels in the DRG is discussed 
      briefly.
FAU - Ha, S O
AU  - Ha SO
AD  - Department of Anatomy, School of Medicine, Kyungpook National University, 2-101 
      Dongin Dong, Taegu 700-422, South Korea.
FAU - Yoo, H J
AU  - Yoo HJ
FAU - Park, S Y
AU  - Park SY
FAU - Hong, H S
AU  - Hong HS
FAU - Kim, D S
AU  - Kim DS
FAU - Cho, H J
AU  - Cho HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Capsaicin/*pharmacology
MH  - Ganglia, Spinal/cytology/drug effects/*metabolism
MH  - Gene Expression Regulation/drug effects
MH  - Male
MH  - Neurons/cytology/*metabolism
MH  - Protein Biosynthesis/drug effects
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/cytology/drug effects/*metabolism
MH  - Transcription, Genetic/drug effects
EDAT- 2000/09/23 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/23 11:00
PHST- 2000/09/23 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/23 11:00 [entrez]
AID - S0169328X00001443 [pii]
AID - 10.1016/s0169-328x(00)00144-3 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 2000 Sep 30;81(1-2):181-6. doi: 
      10.1016/s0169-328x(00)00144-3.