PMID- 11002985
OWN - NLM
STAT- MEDLINE
DCOM- 20010208
LR  - 20190910
IS  - 0932-0113 (Print)
IS  - 0932-0113 (Linking)
VI  - 86
IP  - 9
DP  - 2000 Sep
TI  - Immunisation of lambs with drug-abbreviated Haemonchus contortus infections: 
      protection against homologous and heterologous challenge.
PG  - 758-61
AB  - Haemonchus contortus is known as a prolific parasite, producing high numbers of 
      eggs. It could therefore be used as a cheap source of larvae for immunisation of 
      lambs. The value of immunisation would be improved if the immunity produced gave 
      protection against not only homologous but also heterologous infections. Because 
      antibody cross-reactivity between Haemonchus and Ostertagia has been well 
      established, we wanted to know whether drug-abbreviated infections of H. 
      contortus would stimulate production of antibodies that would cross-react with 
      Trichostrongylus colubriformis. The results obtained from these trials indicated 
      that H. contortus drug-abbreviated infections produced significant immunity 
      against not only Haemonchus but also O. circumcincta. Immunisation increased the 
      level of immunoglobulin E (IgE) and IgE-specific antibodies against T. 
      colubriformis, but the differences between experimental and control animals were 
      not statistically significant. Significantly higher levels of IgG-specific 
      antibodies against T. colubriformis were observed.
FAU - Stankiewicz, M
AU  - Stankiewicz M
AD  - Animal and Food Sciences Division, Lincoln University, Canterbury, New Zealand. 
      stankiem@lincoln.ac.nz
FAU - Hadas, E
AU  - Hadas E
FAU - Shaw, R
AU  - Shaw R
FAU - Green, R
AU  - Green R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Parasitol Res
JT  - Parasitology research
JID - 8703571
RN  - 0 (Antibodies, Helminth)
RN  - 0 (Antigens, Helminth)
RN  - 0 (Antigens, Heterophile)
RN  - 0 (Antinematodal Agents)
RN  - 0 (Benzimidazoles)
RN  - 2880D3468G (Levamisole)
RN  - OMP2H17F9E (oxfendazole)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antibodies, Helminth/blood
MH  - Antigens, Helminth/*immunology
MH  - Antigens, Heterophile/*immunology
MH  - Antinematodal Agents/*therapeutic use
MH  - Benzimidazoles/therapeutic use
MH  - Cross Reactions/immunology
MH  - Haemonchiasis/immunology/prevention & control/*veterinary
MH  - Haemonchus/*immunology/isolation & purification
MH  - Immunization
MH  - Levamisole/therapeutic use
MH  - Ostertagia/immunology/isolation & purification
MH  - Ostertagiasis/immunology/prevention & control/veterinary
MH  - Random Allocation
MH  - Sheep
MH  - Sheep Diseases/*immunology/parasitology/prevention & control
MH  - Treatment Outcome
MH  - Trichostrongylosis/immunology/prevention & control/veterinary
MH  - Trichostrongylus/immunology/isolation & purification
EDAT- 2000/09/26 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/09/26 11:00
PHST- 2000/09/26 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/09/26 11:00 [entrez]
AID - 10.1007/pl00008564 [doi]
PST - ppublish
SO  - Parasitol Res. 2000 Sep;86(9):758-61. doi: 10.1007/pl00008564.