PMID- 11004814
OWN - NLM
STAT- MEDLINE
DCOM- 20001201
LR  - 20131121
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 58
IP  - 9
DP  - 2000 Sep
TI  - [Comparison between histamine H2-blocker and proton pump inhibitor on the effects 
      of initial treatment in reflux esophagitis].
PG  - 1847-52
AB  - I have reviewed the comparison between histamine H2 blocker(H2-RA) and proton 
      pump inhibitor(PPI) on the effects of initial treatment in patients with reflux 
      esophagitis. Pathophysiology of reflux esophagitis has been thought to be 
      gastroesophageal reflux of the gastric acid, due to motor dysfunctions of the 
      esophagus and the stomach. Endoscopic healing rate of reflux esophagitis is 
      significantly higher 84% on PPI treatment than 52% on H2-RA treatment at 8 weeks 
      period. Because suppression of the gastric acid secretion is significantly 
      stronger and longer on PPI than H2-RA, especially this suppression is markedly 
      found in day time and also night time. On the initial treatment of reflux 
      esophagitis, PPI is choice so-called "step down therapy" after healing, H2-RA 
      and/or prokinetic drugs are treated as maintenance therapy.
FAU - Harasawa, S
AU  - Harasawa S
AD  - Saitama-Ken Saiseikai Kawaguchi General Hospital.
LA  - jpn
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Antacids)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Antacids/*therapeutic use
MH  - Enzyme Inhibitors/*therapeutic use
MH  - Esophagitis, Peptic/*drug therapy/physiopathology
MH  - Histamine H2 Antagonists/*therapeutic use
MH  - Humans
MH  - *Proton Pump Inhibitors
RF  - 16
EDAT- 2000/09/27 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/27 11:00
PHST- 2000/09/27 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/27 11:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 2000 Sep;58(9):1847-52.