PMID- 11007969
OWN - NLM
STAT- MEDLINE
DCOM- 20001018
LR  - 20231213
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 481
IP  - 3
DP  - 2000 Sep 22
TI  - Elevated expression of membrane type 1 metalloproteinase (MT1-MMP) in reactive 
      astrocytes following neurodegeneration in mouse central nervous system.
PG  - 227-34
AB  - Reactive astrocytes occurring in response to neurodegeneration are thought to 
      play an important role in neuronal regeneration by upregulating the expression of 
      extracellular matrix (ECM) components as well as the ECM degrading 
      metalloproteinases (MMPs). We examined the mRNA levels and cellular distribution 
      of membrane type matrix metalloproteinase 1 (MT1-MMP) and tissue inhibitors 1-4 
      of MMPs (TIMPs) in brain stem and spinal cord of wobbler (WR) mutant mice 
      affected by progressive neurodegeneration and astrogliosis. MT1-MMP, TIMP-1 and 
      TIMP-3 mRNA levels were elevated, whereas TIMP-2 and TIMP-4 expression was not 
      affected. MT1-MMP was expressed in reactive astrocytes of WR. In primary 
      astrocyte cultures, MT1-MMP mRNA was upregulated by exogeneous tumor necrosis 
      factor alpha. Increased plasma membrane and secreted MMP activities were found in 
      primary WR astrocytes.
FAU - Rathke-Hartlieb, S
AU  - Rathke-Hartlieb S
AD  - Developmental Biology and Molecular Pathology, WY, University of Bielefeld, 
      D-33501 Bielefeld, Germany.
FAU - Budde, P
AU  - Budde P
FAU - Ewert, S
AU  - Ewert S
FAU - Schlomann, U
AU  - Schlomann U
FAU - Staege, M S
AU  - Staege MS
FAU - Jockusch, H
AU  - Jockusch H
FAU - Bartsch, J W
AU  - Bartsch JW
FAU - Frey, J
AU  - Frey J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Mmp14 protein, mouse)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-3)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
RN  - EC 3.4.24.- (Matrix Metalloproteinases, Membrane-Associated)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.80 (Matrix Metalloproteinase 14)
SB  - IM
MH  - Animals
MH  - Astrocytes/*enzymology/immunology/pathology
MH  - Cell Line
MH  - Cells, Cultured
MH  - Central Nervous System/*enzymology/pathology
MH  - Enzyme Induction/genetics/immunology
MH  - Gene Expression Regulation/immunology
MH  - Matrix Metalloproteinase 14
MH  - Matrix Metalloproteinases, Membrane-Associated
MH  - Metalloendopeptidases/*biosynthesis/genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Neurologic Mutants
MH  - Neurodegenerative Diseases/*enzymology/genetics/pathology
MH  - RNA, Messenger/biosynthesis
MH  - Recombinant Proteins/pharmacology
MH  - Tissue Inhibitor of Metalloproteinase-1/biosynthesis/genetics
MH  - Tissue Inhibitor of Metalloproteinase-2/biosynthesis/genetics
MH  - Tissue Inhibitor of Metalloproteinase-3/biosynthesis/genetics
MH  - Tissue Inhibitor of Metalloproteinases/biosynthesis/genetics
MH  - Tumor Necrosis Factor-alpha/pharmacology
MH  - Up-Regulation/genetics/immunology
MH  - Tissue Inhibitor of Metalloproteinase-4
EDAT- 2000/09/29 11:00
MHDA- 2000/10/21 11:01
CRDT- 2000/09/29 11:00
PHST- 2000/09/29 11:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/09/29 11:00 [entrez]
AID - S0014-5793(00)02011-1 [pii]
AID - 10.1016/s0014-5793(00)02011-1 [doi]
PST - ppublish
SO  - FEBS Lett. 2000 Sep 22;481(3):227-34. doi: 10.1016/s0014-5793(00)02011-1.