PMID- 11008115 OWN - NLM STAT- MEDLINE DCOM- 20001117 LR - 20191210 IS - 1286-4579 (Print) IS - 1286-4579 (Linking) VI - 2 IP - 10 DP - 2000 Aug TI - Interleukin-18 (IL-18) and infectious diseases, with special emphasis on diseases induced by intracellular pathogens. PG - 1257-63 AB - Interleukin-18 (IL-18) is a novel cytokine mainly produced by activated macrophages. IL-18 was originally called interferon-gamma inducing factor, due to its action in inducing IFN-gamma secretion from Th1 cells, NK cells and NKT cells. It has been reported that IL-18 may play important roles in various diseases including cancer and infectious diseases. This review deals with the roles of IL-18 in infectious diseases, with special emphasis on IL-18 in infectious diseases caused by intracellular pathogens including Mycobacterium tuberculosis, Mycobacterium leprae, Listeria monocytogenes and Salmonella typhimurium. FAU - Sugawara, I AU - Sugawara I AD - Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti-tuberculosis Association, 3-1-24 Matsuyama, Kiyose, Tokyo 204-0022, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - France TA - Microbes Infect JT - Microbes and infection JID - 100883508 RN - 0 (Interleukin-18) SB - IM MH - Animals MH - Bacterial Infections/metabolism/microbiology MH - Humans MH - Infections/*metabolism/microbiology/pathology MH - Interleukin-18/*metabolism MH - Listeriosis/metabolism/pathology MH - Mycobacterium Infections/metabolism/microbiology/pathology MH - Salmonella Infections/metabolism/pathology MH - Virus Diseases/metabolism/microbiology RF - 49 EDAT- 2000/09/29 11:00 MHDA- 2001/02/28 10:01 CRDT- 2000/09/29 11:00 PHST- 2000/09/29 11:00 [pubmed] PHST- 2001/02/28 10:01 [medline] PHST- 2000/09/29 11:00 [entrez] AID - S1286-4579(00)01279-X [pii] AID - 10.1016/s1286-4579(00)01279-x [doi] PST - ppublish SO - Microbes Infect. 2000 Aug;2(10):1257-63. doi: 10.1016/s1286-4579(00)01279-x.