PMID- 11008329
OWN - NLM
STAT- MEDLINE
DCOM- 20001024
LR  - 20131121
IS  - 0043-5341 (Print)
IS  - 0043-5341 (Linking)
VI  - 150
IP  - 12
DP  - 2000
TI  - [Effect of ACE-inhibitors on left ventricular remodeling after acute anterior or 
      posterior myocardial infarct. Cine- magnetic resonance tomography study].
PG  - 249-55
AB  - The question whether patients with posterior infarctions (PMI) have a comparable 
      benefit of an ACE-inhibitor therapy to those with anterior infarction (AMI) is 
      still open. The study was undertaken to investigate the different influence of 
      ACE inhibitors on the remodeling of the left ventricle after AMI or PMI. 52 
      patients (Pt.) (17 female, 38-73 years) were randomized to receive either 25-75 
      mg/day captopril (C) or 5-20 mg/day fosinopril (F) beginning on day 7 after acute 
      myocardial infarction. 28 Pt. had AMI, 24 Pt. PMI. Infarct size was determined by 
      the creatine kinase integral method. 50 Pt. were examined by cine magnetic 
      resonance imaging 1 and 26 weeks after infarction. We determined: left 
      ventricular end-diastolic (LVEDVI) and end-systolic (LVESVI) volume index, 
      ejection fraction (EF), infarction weight (IW), left ventricular muscle mass 
      (MM), systolic wall thickening (SWT) and motility (MOT) of the vital myocardium, 
      and clinical behavior according to the guidelines of the New York Heart 
      Association (NYHA). The results were compared with those of a sample (V) without 
      ACE inhibitor therapy (10 females, 21 males, 36-75 years, 19 AMI, 12 PMI). There 
      were no significant differences between C and F. Without ACE-inhibition therapy 
      LVEDVI increased by 28.2% in AMI, by 18.4% in PMI (p < 0.001), with 
      ACE-inhibition by 13.7% in AMI and by 9.9% in PMI (p < 0.001). LVESVI increased 
      in V by 40.1% in AMI, by 28.5% in PMI (p < 0.001). With ACE-inhibitor we found an 
      increase of 11.2% in AMI and 5.3% in PMI (p < 0.001). EF decreased without 
      ACE-inhibitor by 18.7% in AMI and by 10.2% in PMI (p < 0.001), with 
      ACE-inhibition increased by 4.3% in AMI and PMI, respectively (n. s.). NYHA got 
      better in all groups, by 17.4% in AMI and 20.8% in PMI without ACE-inhibitor 
      (n.s.), by 45.5% in AMI and 31.6% in PMI with ACE-inhibitor (p < 0.001). IG 
      increased by 15.5% in AMI and 8.8% in PMI in V (p < 0.001), by 11.2% in AMI and 
      5.3% in PMI with C or F (p < 0.001). MM got bigger in V by 16.6% in AMI and 12.7% 
      in PMI (p < 0.05), with ACE-inhibitor by 11.7% in AMI and 8.0% in PMI (p < 0.05). 
      sWD increased by 12.9% in AMI and by 6.7% in PMI in V (p < 0.01), by 37.1% in AMI 
      and 88.0% in PMI with C or F (p < 0.001). MOT decreased by 39.6% in AMI and 14.9% 
      in PMI without ACE-inhibition (p < 0.001) and increased by 4.3% in AMI and by 
      5.0% in PMI with ACE-inhibitor (n. s.). All differences between V and the 
      ACE-inhibitor groups were significant. Even patients with PMI clearly benefit 
      from ACE-inhibitor therapy, but less than those with AMI. Captopril and 
      fosinopril show no different effects after myocardial infarction.
FAU - Konermann, M
AU  - Konermann M
AD  - Medizinische Klinik, Marienkrankenhaus, Kassel, Deutschland. 
      MKH-Kassel.Konermann@T-online.de
FAU - Odenthal, H J
AU  - Odenthal HJ
FAU - Altmann, C
AU  - Altmann C
FAU - Laschewski, F
AU  - Laschewski F
FAU - Rawert, B
AU  - Rawert B
FAU - Trappe, H J
AU  - Trappe HJ
FAU - Sanner, B M
AU  - Sanner BM
LA  - ger
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Einfluss von ACE-Hemmern auf das Remodeling des linken Ventrikels nach akutem 
      Vorder- oder Hinterwandinfarkt. Untersuchungen mit der 
      Cine-Magnetresonanztomographie.
PL  - Austria
TA  - Wien Med Wochenschr
JT  - Wiener medizinische Wochenschrift (1946)
JID - 8708475
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 9G64RSX1XD (Captopril)
RN  - R43D2573WO (Fosinopril)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiotensin-Converting Enzyme Inhibitors/pharmacology/*therapeutic use
MH  - Captopril/pharmacology/*therapeutic use
MH  - Female
MH  - Fosinopril/pharmacology/*therapeutic use
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*drug therapy/pathology/physiopathology
MH  - Stroke Volume/drug effects
MH  - Treatment Outcome
MH  - Ventricular Function, Left/drug effects
MH  - Ventricular Remodeling/*drug effects
EDAT- 2000/09/29 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/29 11:00
PHST- 2000/09/29 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/29 11:00 [entrez]
PST - ppublish
SO  - Wien Med Wochenschr. 2000;150(12):249-55.