PMID- 11011048
OWN - NLM
STAT- MEDLINE
DCOM- 20001207
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 406
IP  - 1
DP  - 2000 Oct 6
TI  - Serum leptin levels after central and systemic injection of a serotonin 
      precursor, 5-hydroxytryptophan, in mice.
PG  - 159-62
AB  - Effects of peripheral and central injections of a serotonin (5-hydroxytryptamine, 
      5-HT) precursor, 5-hydroxytryptophan (5-HTP), on serum leptin levels were studied 
      in mice. Intracerebroventricular (i.c.v.) injection of 5-HTP or 5-HT did not 
      increase serum leptin levels, although the peripheral injection of 5-HTP elicited 
      an apparent hyperleptinemia. The elevation of serum leptin levels in mice induced 
      by the peripheral injection of 5-HTP was inhibited by pretreatment with the 
      peripheral aromatic amino acid decarboxylase inhibitor, benserazide. Furthermore, 
      the peripheral injection of 5-HT increased serum leptin levels. These results 
      suggest that the hyperleptinemia following systemic injection of 5-HTP is 
      elicited by 5-HT formed in the peripheral system.
FAU - Yamada, J
AU  - Yamada J
AD  - Department of Pharmacology, Kobe Pharmaceutical University, Motoyamakita-machi, 
      Higashinada-ku, 658-8558, Kobe, Japan. j-yamada@kobepharma-u.ac.jp
FAU - Ujikawa, M
AU  - Ujikawa M
FAU - Sugimoto, Y
AU  - Sugimoto Y
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Leptin)
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - 762OS3ZEJU (Benserazide)
RN  - C1LJO185Q9 (5-Hydroxytryptophan)
SB  - IM
MH  - 5-Hydroxytryptophan/*pharmacology
MH  - Animals
MH  - Benserazide/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Leptin/*blood
MH  - Male
MH  - Mice
MH  - Serotonin/pharmacology
MH  - Serotonin Agents/pharmacology
MH  - Time Factors
EDAT- 2000/09/30 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/30 11:00
PHST- 2000/09/30 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/30 11:00 [entrez]
AID - S0014-2999(00)00624-5 [pii]
AID - 10.1016/s0014-2999(00)00624-5 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2000 Oct 6;406(1):159-62. doi: 10.1016/s0014-2999(00)00624-5.