PMID- 11011754
OWN - NLM
STAT- MEDLINE
DCOM- 20001011
LR  - 20190921
IS  - 0277-0903 (Print)
IS  - 0277-0903 (Linking)
VI  - 37
IP  - 6
DP  - 2000 Sep
TI  - The association of skin test reactivity, total serum IgE levels, and peripheral 
      blood eosinophilia with asthma in Kuwait.
PG  - 481-8
AB  - There is evidence that elevated serum immunoglobulin E (IgE) and eosinophilia 
      correlate well with allergic skin test reactivity. These parameters have been 
      used as alternative methods to characterize atopic subjects. Skin test reactivity 
      is the only measure used routinely in clinical practice in Kuwait to reflect 
      atopy in asthma patients. This study examines the usefulness of the two other 
      parameters of atopy in patients with asthma, and to determine the most common 
      allergens involved in Kuwait. Between 1998 and 1999, 101 asthma patients and 33 
      healthy controls were recruited for this study. Skin sensitivity test, serum 
      total and specific IgE, total blood eosinophil count (B-EOS), and eosinophil 
      cationic protein (ECP) tests were performed in patients and controls. Nine 
      allergens known to be prevalent in this environment were selected for the skin 
      test and specific IgE test. Spirometry was also measured. These parameters were 
      repeated after 4 weeks of therapy in the patients only. Skin test reaction was 
      positive in 81% of the patients, while total IgE above 200 kU/L was obtained in 
      63% of cases. B-EOS above 300 x 10(3)/L was found in 75% of cases. House dust 
      mite reactivity (positivity) was the most frequently encountered skin allergy, 
      occurring in 28% of the patients. IgE correlated positively with B-EOS and ECP. 
      B-EOS similarly correlated positively with ECP. There was a negative correlation 
      between ECP and forced expiratory volume in 1 sec (FEV1) (% predicted) as 
      expected. At least one positive parameter of atopy was found in 95% of the 
      patients. In 48% of the patients, all three parameters of atopy were found to be 
      positive. Skin test reactivity and elevated IgE were found together in 62% of the 
      cases. This study reveals a significant degree of allergy among patients with 
      asthma in this environment. Skin testing was found to be the most effective 
      measure of atopy in this environment, and correlates well with the other more 
      sensitive newer tests.
FAU - Khadadah, M
AU  - Khadadah M
AD  - Department of Medicine, Faculty of Medicine, Kuwait University, Safat. 
      mousa@hsc.kuniv.edu.kw
FAU - Onadeko, B O
AU  - Onadeko BO
FAU - Ezeamuzie, C I
AU  - Ezeamuzie CI
FAU - Mustafa, H T
AU  - Mustafa HT
FAU - Marouf, R
AU  - Marouf R
FAU - Sugathan, T N
AU  - Sugathan TN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Allergens
MH  - Asthma/*diagnosis/immunology
MH  - *Developing Countries
MH  - Eosinophilia/*diagnosis/immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*diagnosis/immunology
MH  - Immunoglobulin E/*blood
MH  - Kuwait
MH  - Lung Volume Measurements
MH  - Male
MH  - Middle Aged
MH  - *Patch Tests
MH  - Respiratory Hypersensitivity/*diagnosis/immunology
EDAT- 2000/09/30 11:00
MHDA- 2000/10/14 11:01
CRDT- 2000/09/30 11:00
PHST- 2000/09/30 11:00 [pubmed]
PHST- 2000/10/14 11:01 [medline]
PHST- 2000/09/30 11:00 [entrez]
AID - 10.3109/02770900009055474 [doi]
PST - ppublish
SO  - J Asthma. 2000 Sep;37(6):481-8. doi: 10.3109/02770900009055474.