PMID- 11011810
OWN - NLM
STAT- MEDLINE
DCOM- 20010208
LR  - 20191104
IS  - 0094-6176 (Print)
IS  - 0094-6176 (Linking)
VI  - 26 Suppl 1
DP  - 2000
TI  - Low-molecular-weight heparin and cancer.
PG  - 69-77
AB  - Heparin is a familiar anticoagulant drug with properties that may impede tumor 
      growth; it modifies properties of cells that contribute to malignant 
      dissemination such as angiogenesis, growth factor and protease activity, immune 
      function, proliferation, and gene expression. Heparin has antitumor effects in 
      animal models of malignancy, and studies in human malignancy show improved cancer 
      outcome with heparin treatment. Meta-analyses comparing unfractionated heparin 
      (UFH) and low-molecular-weight heparin (LMWH) for treatment of deep-vein 
      thrombosis have shown apparent substantial improvement in cancer outcome in the 
      subset of patients with malignancy who were randomly assigned to receive LMWH. 
      This experience, together with the favorable pharmacokinetic properties of LMWH, 
      provides a rationale for prospective clinical trials of LMWH in patients with 
      cancer. Such trials should provide (a) definitive data on possible antitumor 
      effects of this treatment, (b) insight into possible heterogeneous responses to 
      heparin treatment among different histological types and stages of malignancy, 
      and (c) a setting for exploring mechanisms of antineoplastic effect in human 
      malignancy.
FAU - Zacharski, L R
AU  - Zacharski LR
AD  - VA Medical & Regional Office Center, White River Junction, Vermont 05009, USA. 
      leo.r.zacharski@dartmouth.edu
FAU - Ornstein, D L
AU  - Ornstein DL
FAU - Mamourian, A C
AU  - Mamourian AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Semin Thromb Hemost
JT  - Seminars in thrombosis and hemostasis
JID - 0431155
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - Animals
MH  - Carcinoma, Non-Small-Cell Lung/drug therapy/etiology
MH  - Clinical Trials as Topic
MH  - Disease Models, Animal
MH  - Heparin, Low-Molecular-Weight/*pharmacology/*therapeutic use
MH  - Humans
MH  - Lung Neoplasms
MH  - Neoplasms/complications/*drug therapy
MH  - Research Design
RF  - 58
EDAT- 2000/09/30 11:00
MHDA- 2001/03/03 10:01
CRDT- 2000/09/30 11:00
PHST- 2000/09/30 11:00 [pubmed]
PHST- 2001/03/03 10:01 [medline]
PHST- 2000/09/30 11:00 [entrez]
AID - 10.1055/s-2000-9499 [doi]
PST - ppublish
SO  - Semin Thromb Hemost. 2000;26 Suppl 1:69-77. doi: 10.1055/s-2000-9499.