PMID- 11015481
OWN - NLM
STAT- MEDLINE
DCOM- 20001114
LR  - 20180330
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 130
IP  - 10
DP  - 2000 Oct
TI  - A high carbohydrate versus a high monounsaturated fatty acid diet lowers the 
      atherogenic potential of big VLDL particles in patients with type 1 diabetes.
PG  - 2503-7
AB  - The objective of the present study was to compare the effects of two diets on the 
      atherogenic potential of two VLDL subfractions harvested from fasting subjects by 
      measuring the number and composition of particles and the amount of esterified 
      cholesterol accumulated in macrophages. A high (25%) monounsaturated fatty acid 
      (Mono) diet and a high (61%) carbohydrate (CHO) diet were provided for 4 wk in a 
      randomized crossover design to 19 normolipidemic, nonobese patients with type 1 
      diabetes. The two diets were matched for protein, polyunsaturated/saturated fatty 
      acids, cholesterol and fiber content. The number of circulating big VLDL (S:(f) 
      100-400) particles was greater during the high Mono than during the high CHO diet 
      based on the levels of apolipoprotein B (means +/- SEM): 31.4 +/- 7.4 versus 20.0 
      +/- 3.8 mg/L (P: < 0.025, paired t test). The following variables did not differ 
      during the diet periods: number of small VLDL (S:(f) 20-100) particles, 
      esterified cholesterol accumulated in THP-1 macrophages incubated with the same 
      number of big and small VLDL particles and particle composition. We conclude that 
      a high CHO diet might be preferable to a high Mono diet, on the basis of the 
      premise that more big VLDL particles could increase the atherosclerotic risk in 
      patients with diabetes.
FAU - Georgopoulos, A
AU  - Georgopoulos A
AD  - Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55417, USA.
FAU - Bantle, J P
AU  - Bantle JP
FAU - Noutsou, M
AU  - Noutsou M
FAU - Hoover, H A
AU  - Hoover HA
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Cholesterol Esters)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Fatty Acids, Monounsaturated)
RN  - 0 (Lipoproteins, VLDL)
RN  - 0 (Phospholipids)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Arteriosclerosis/blood/*prevention & control
MH  - Cholesterol Esters/blood
MH  - Cross-Over Studies
MH  - Diabetes Mellitus, Type 1/blood/*complications
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dietary Fats, Unsaturated/*administration & dosage
MH  - Fasting
MH  - Fatty Acids, Monounsaturated/*administration & dosage
MH  - Female
MH  - Humans
MH  - Lipoproteins, VLDL/*blood
MH  - Macrophages/metabolism
MH  - Male
MH  - Middle Aged
MH  - Particle Size
MH  - Phospholipids/blood
MH  - Triglycerides/blood
EDAT- 2000/10/04 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/04 11:00
PHST- 2000/10/04 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/04 11:00 [entrez]
AID - 10.1093/jn/130.10.2503 [doi]
PST - ppublish
SO  - J Nutr. 2000 Oct;130(10):2503-7. doi: 10.1093/jn/130.10.2503.