PMID- 11016314
OWN - NLM
STAT- MEDLINE
DCOM- 20001017
LR  - 20190628
IS  - 0003-4975 (Print)
IS  - 0003-4975 (Linking)
VI  - 70
IP  - 3
DP  - 2000 Sep
TI  - Reperfusion injury associated with one-fourth of deaths after coronary artery 
      bypass grafting.
PG  - 807-12
AB  - BACKGROUND: This study of reperfusion injury after coronary artery bypass 
      grafting focuses on its contribution to fatal outcome, on its connection with 
      myocardial infarction (MI) and on risk factors. METHODS: A consecutive series of 
      190 patients (mean age 61.7+/-8.9 years) dying within 30 days following coronary 
      artery bypass grafting was autopsied with concomitant postmortem angiography 
      during 1980 to 1993. RESULTS: Reperfusion injury was revealed in 49 (25.8%) 
      patients, with concomitant MI in almost all (46 of 49) (p < 0.01). Reperfusion 
      injury occurred in association with preoperative New York Heart Association 
      (NYHA) III classification (p < 0.05), coronary endarterectomy (p < 0.01), long 
      aortic clamping time (p < 0.01), and short postoperative survival (p < 0.05). 
      CONCLUSIONS: Reperfusion injury was observed in one fourth of the deaths in 
      association with MI. It occurred more often in patients with preoperative NYHA 
      III symptoms and in those in whom endarterectomy was carried out and the anoxic 
      time of the myocardium was longer. The shorter postoperative survival time 
      indicates the lethal nature of this complication.
FAU - Weman, S M
AU  - Weman SM
AD  - Department of Forensic Medicine, Helsinki University, Finland.
FAU - Karhunen, P J
AU  - Karhunen PJ
FAU - Penttila, A
AU  - Penttila A
FAU - Jarvinen, A A
AU  - Jarvinen AA
FAU - Salminen, U S
AU  - Salminen US
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
SB  - IM
MH  - Angiography
MH  - Cause of Death
MH  - Coronary Artery Bypass/*mortality
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/mortality
MH  - Myocardial Reperfusion Injury/*mortality
MH  - Prospective Studies
MH  - Time Factors
EDAT- 2000/10/04 11:00
MHDA- 2000/10/21 11:01
CRDT- 2000/10/04 11:00
PHST- 2000/10/04 11:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/10/04 11:00 [entrez]
AID - S0003-4975(00)01638-6 [pii]
AID - 10.1016/s0003-4975(00)01638-6 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2000 Sep;70(3):807-12. doi: 10.1016/s0003-4975(00)01638-6.