PMID- 11017109
OWN - NLM
STAT- MEDLINE
DCOM- 20010419
LR  - 20240104
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 1
IP  - 4
DP  - 2000 Oct
TI  - DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking.
PG  - 353-7
AB  - Dendritic cells (DCs) are recruited from blood into tissues to patrol for foreign 
      antigens. After antigen uptake and processing, DCs migrate to the secondary 
      lymphoid organs to initiate immune responses. We now show that DC-SIGN, a 
      DC-specific C-type lectin, supports tethering and rolling of DC-SIGN-positive 
      cells on the vascular ligand ICAM-2 under shear flow, a prerequisite for 
      emigration from blood. The DC-SIGN-ICAM-2 interaction regulates chemokine-induced 
      transmigration of DCs across both resting and activated endothelium. Thus, 
      DC-SIGN is central to the unusual trafficking capacity of DCs, further supported 
      by the expression of DC-SIGN on precursors in blood and on immature and mature 
      DCs in both peripheral and lymphoid tissues.
FAU - Geijtenbeek, T B
AU  - Geijtenbeek TB
AD  - Department of Tumor Immunology, University Medical Center St Radboud, Philips van 
      Leydenlaan 25, Nijmegen 6525 EX, The Netherlands.
FAU - Krooshoop, D J
AU  - Krooshoop DJ
FAU - Bleijs, D A
AU  - Bleijs DA
FAU - van Vliet, S J
AU  - van Vliet SJ
FAU - van Duijnhoven, G C
AU  - van Duijnhoven GC
FAU - Grabovsky, V
AU  - Grabovsky V
FAU - Alon, R
AU  - Alon R
FAU - Figdor, C G
AU  - Figdor CG
FAU - van Kooyk, Y
AU  - van Kooyk Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Antigens, CD)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (ICAM2 protein, human)
RN  - 0 (Lectins)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Antigens, CD/*immunology
MH  - Cell Adhesion Molecules/*immunology
MH  - Cell Differentiation
MH  - Cell Movement/*immunology
MH  - Cells, Cultured
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Immunity, Cellular
MH  - Lectins/*immunology
MH  - *Lectins, C-Type
MH  - Receptors, Cell Surface/*immunology
EDAT- 2001/03/23 10:00
MHDA- 2001/04/21 10:01
CRDT- 2001/03/23 10:00
PHST- 2001/03/23 10:00 [pubmed]
PHST- 2001/04/21 10:01 [medline]
PHST- 2001/03/23 10:00 [entrez]
AID - 10.1038/79815 [doi]
PST - ppublish
SO  - Nat Immunol. 2000 Oct;1(4):353-7. doi: 10.1038/79815.