PMID- 11018490
OWN - NLM
STAT- MEDLINE
DCOM- 20001214
LR  - 20190921
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 111
IP  - 10
DP  - 2000 Oct
TI  - Excitability recovery curve of the sympathetic skin response in healthy 
      volunteers and patients with palmar hyperhidrosis.
PG  - 1767-70
AB  - OBJECTIVES: Patients with primary palmar hyperhidrosis (PPH) might exhibit 
      hyperexcitability of the reflex circuits involved in sweating. We hypothesized 
      that this hyperexcitability could become evident in the study of the excitability 
      recovery curve of the sympathetic sudomotor skin response (SSR). METHODS: In 10 
      patients with PPH and 10 healthy volunteers used as control subjects, we recorded 
      the SSR in the palm of the right hand to pairs of median nerve electrical shocks 
      separated by inter-stimuli intervals (ISIs) ranging from 0.5 to 3.5 s. The 
      amplitude of the SSR generated by the second stimulus (SSR2) was expressed as a 
      percentage of that generated by the first (SSR1), and compared between control 
      subjects and patients for each ISI. RESULTS: None of the control subjects showed 
      a recovery of the SSR for ISIs of 1.5 s or less. On the contrary, patients showed 
      a statistically significant enhancement of the SSR excitability recovery curve, 
      with onset of recovery at 1.5 s in 5 patients. Two patients showed a double peak 
      response to single electrical stimulation and were not considered in the 
      calculation of the SSR recovery curve. Mean excitability recovery percentages 
      were larger in patients than in control subjects at ISIs of 2, 2.5 and 3 s. 
      CONCLUSIONS: The enhancement of the SSR recovery curve in patients with PPH 
      suggests hyperexcitability of the somatosympathetic polisynaptic pathway involved 
      in sweating. This could partly underlie the pathophysiology of PPH.
FAU - Manca, D
AU  - Manca D
AD  - Unitat d'EMG, Servei de Neurologia, Departamento de Medicina, IDIBAPS, Hospital 
      Clinic, Facultad de Medicina, Universitat de Barcelona, Villaroel, 170, 08036, 
      Barcelona, Spain.
FAU - Valls-Sole, J
AU  - Valls-Sole J
FAU - Callejas, M A
AU  - Callejas MA
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Electric Stimulation
MH  - Electromyography
MH  - Female
MH  - Humans
MH  - Hyperhidrosis/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Reaction Time/physiology
MH  - *Skin Physiological Phenomena
MH  - Sympathetic Nervous System/*physiology
EDAT- 2000/10/06 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/06 11:00
PHST- 2000/10/06 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/06 11:00 [entrez]
AID - S1388-2457(00)00394-1 [pii]
AID - 10.1016/s1388-2457(00)00394-1 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2000 Oct;111(10):1767-70. doi: 10.1016/s1388-2457(00)00394-1.